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Identification of genes and signaling pathways associated with the pathogenesis of juvenile spondyloarthritis 期刊论文

编号：

005fd3fa-3632-4d14-9676-f9234a678eb8
作者：

Wang, Zhe#^[1,2]Han, Yudi#^[3]Zhang, Zhaoqing#^[4]Jia, Cunfeng^[4];Zhao, Qiang^[4];Song, Wei^[5];Chen, Tao^[6];Zhang, Yifan^[7];Wang, Xiuhui*^[8]
语种：

English
期刊：

MOLECULAR MEDICINE REPORTS ISSN：1791-2997 2018 年 18 卷 2 期 (1263 - 1270) ; AUG
收录：
关键词：

differentially expressed genes juvenile spondyloarthritis mitogen-activated protein kinase 1 signaling pathway inflammation
摘要：

The aim of the present study was to identify key genes and signaling pathways associated with the pathogenesis of juvenile spondyloarthritis (JSA). The gene expression profile dataset GSE58667, including data from 15 human whole blood samples collected from 11 patients with JSA and four healthy controls, was analyzed to identify differentially expressed genes (DEGs) associated with disease characteristics. Additionally, Gene Ontology term and Kyoto Encyclopedia of Genes and Genomes pathway enrichment analyses of the DEGs were performed. Protein-protein, microRNA-transcription factor and chemical-gene interaction networks were constructed. A total of 326 DEGs, 196 upregulated and 130 downregulated, were identified. DEGs, including C-X-C motif chemokine ligand 5 (CXCL5), BCL2 interacting protein 3 like (BNIP3L), dual specificity phosphatase 5 (DUSP5) and tumor protein p53 (TP53) were enriched in functions associated with apoptosis, the cell cycle and immune responses. KEGG pathway enrichment analysis revealed that pathways associated with inflammation and the mitogen-activated protein kinase 1 (MAPK) signaling pathway were the most enriched by DEGs. The results of the present study indicated that the MAPK signaling pathway and four genes, including CXCL5, BNIP3L, DUSP5 and TP53, may be implicated in the pathogenesis of JSA.
推荐引用方式
GB/T 7714：

Wang Zhe,Han Yudi,Zhang Zhaoqing, et al. Identification of genes and signaling pathways associated with the pathogenesis of juvenile spondyloarthritis [J].MOLECULAR MEDICINE REPORTS,2018,18(2):1263-1270.
APA：

Wang Zhe,Han Yudi,Zhang Zhaoqing,Jia Cunfeng,&Wang Xiuhui.(2018).Identification of genes and signaling pathways associated with the pathogenesis of juvenile spondyloarthritis .MOLECULAR MEDICINE REPORTS,18(2):1263-1270.
MLA：

Wang Zhe, et al. "Identification of genes and signaling pathways associated with the pathogenesis of juvenile spondyloarthritis" .MOLECULAR MEDICINE REPORTS 18,2(2018):1263-1270.
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