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Nanoparticles of 2-deoxy-D-glucose functionalized poly(ethylene glycol)-co-poly(trimethylene carbonate) for dual-targeted drug delivery in glioma treatment 期刊论文

编号：

01b21438-5d69-4c7d-b677-1dd99535a6ee
作者：

Jiang, Xinyi(姜新义)#^[1,2]Xin, Hongliang(辛洪亮)^[1,3]Ren, Qiuyue^[1];Gu, Jijin(顾吉晋)^[1]Zhu, Lingjun^[4];Du, Fengyi^[5];Feng, Chunlai^[2];Xie, Yike^[1];Sha, Xianyi(沙先谊)^[1]Fang, Xiaoling(方晓玲)*^[1]
语种：

English
期刊：

BIOMATERIALS ISSN：0142-9612 2014 年 35 卷 1 期 (518 - 529) ; JAN
收录：
关键词：

Glioma Dual-targeted drug delivery system Glucose transporter Endocytic mechanism Avascular glioma spheroids
摘要：

Based on the facilitative glucose transporter (GLUT) over-expression on both blood-brain barrier (BBB) and glioma cells, 2-deoxy-D-glucose modified poly(ethylene glycol)-co-poly(trimethylene carbonate) nanoparticles (DGlu-NP) were developed as a potential dual-targeted drug delivery system for enhancing the BBB penetration via GLUT-mediated transcytosis and improving the drug accumulation in the glioma via GLUT-mediated endocytosis. In vitro physicochemical characterization of the dual-targeted nanoparticulate system presented satisfactory size of 71 nm with uniform distribution, high encapsulation efficiency and adequate loading capacity of paclitaxel (PTX). Compared with non-glucosylated nanoparticles (NP), a significantly higher amount of DGlu-NP was internalized by RG-2 glioma cells through caveolae-mediated and clathrin-mediated endocytosis. Both of the transport ratios across the in vitro BBB model and the cytotoxicity of RG-2 cells after crossing the BBB were significantly greater of DGlu-NP/PTX than that of NP/PTX. In vivo fluorescent image indicated that DGlu-NP had high specificity and efficiency in intracranial tumor accumulation. The anti-glioblastoma efficacy of DGlu-NP/PTX was significantly enhanced in comparison with that of Taxol and NP/PTX. Preliminary safety tests showed no acute toxicity to hematological system, liver, kidney, heart, lung and spleen in mice after intravenous administration at a dose of 100 mg/kg blank DGlu-NP per day for a week. Therefore, these results indicated that DGlu-NP developed in this study could be a potential dual-targeted vehicle for brain glioma therapy. (C) 2013 Elsevier Ltd. All rights reserved.
推荐引用方式
GB/T 7714：

Jiang Xinyi,Xin Hongliang,Ren Qiuyue, et al. Nanoparticles of 2-deoxy-D-glucose functionalized poly(ethylene glycol)-co-poly(trimethylene carbonate) for dual-targeted drug delivery in glioma treatment [J].BIOMATERIALS,2014,35(1):518-529.
APA：

Jiang Xinyi,Xin Hongliang,Ren Qiuyue,Gu Jijin,&Fang Xiaoling.(2014).Nanoparticles of 2-deoxy-D-glucose functionalized poly(ethylene glycol)-co-poly(trimethylene carbonate) for dual-targeted drug delivery in glioma treatment .BIOMATERIALS,35(1):518-529.
MLA：

Jiang Xinyi, et al. "Nanoparticles of 2-deoxy-D-glucose functionalized poly(ethylene glycol)-co-poly(trimethylene carbonate) for dual-targeted drug delivery in glioma treatment" .BIOMATERIALS 35,1(2014):518-529.

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