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P21 signaling pathway and activation of p53 pathway in breast cancer 期刊论文

编号：

01ef4359-2dcc-4c05-a8de-4f8c1f4564a3
作者：

Chen, Miaomiao^[1,2];Zhang, Hongqin^[1,2];Zhang, Guihong^[1,2];Zhong, Ailing(郭林)^[1,2]Ma, Qian^[1,2];Kai, Jinyan^[1,2];Tong, Yin^[1];Xie, Suhong^[1];Wang, Yanchun^[1];Zheng, Hui(郑慧)^[1]Guo, Lin(郭林)^[1,2]Lu, Renquan(卢仁泉)*^[1,2]
语种：

English
期刊：

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS ISSN：0006-291X 2018 年 507 卷 1-4 期 (74 - 82) ; DEC 9
收录：
关键词：

TPX2 Breast cancer Cell apoptosis AKT signaling pathway p53
摘要：

Targeting protein for Xenopus kinesin-like protein 2 (TPX2) is a microtubule-associated protein required for mitosis and spindle assembly. Previous studies showed that TPX2 is overexpressed in various human cancers and promotes cancer progression. In this study, the differentially expressed genes including TPX2 were screened in GEO database for gene expression microarray of breast cancer. The TPX2 expression level was significantly increased in breast cancer cells and the breast malignant tissues compared with those controls. In vitro experiment further confirmed that knockdown of TPX2 by small hairpin RNA inhibited breast cancer cell proliferatio, migration, and induced cell apoptosis. TPX2 silencing decreased the expression of PI3K and extent of AKT phosphorylation, as well as increased expression of p53 and p21. Taken together, our findings indicate that TPX2 silencing negatively regulates the PI3K/AKT and activates p53 signaling pathway by which breast cancer cells proliferation were inhibited whereas cellulars apoptosis were accelerated, suggesting that TPX2 may be a potential target for anticancer therapy in breast cancer. (C) 2018 Published by Elsevier Inc.
推荐引用方式
GB/T 7714：

Chen Miaomiao,Zhang Hongqin,Zhang Guihong, et al. Targeting TPX2 suppresses proliferation and promotes apoptosis via repression of the PI3k/AKT/P21 signaling pathway and activation of p53 pathway in breast cancer [J].BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS,2018,507(1-4):74-82.
APA：

Chen Miaomiao,Zhang Hongqin,Zhang Guihong,Zhong Ailing,&Lu Renquan.(2018).Targeting TPX2 suppresses proliferation and promotes apoptosis via repression of the PI3k/AKT/P21 signaling pathway and activation of p53 pathway in breast cancer .BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS,507(1-4):74-82.
MLA：

Chen Miaomiao, et al. "Targeting TPX2 suppresses proliferation and promotes apoptosis via repression of the PI3k/AKT/P21 signaling pathway and activation of p53 pathway in breast cancer" .BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS 507,1-4(2018):74-82.

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