Age-related hearing loss (ARHL) has been considered as a promising modifiable risk factor for cognitive impairment and dementia. Nonetheless, it is still unclear whether age-related hearing loss associates with neurodegenerative biomarkers of Alzheimer's disease (AD). Participants with ARHL were selected from the established Alzheimer's Disease Neuroimaging Initiative (ADNI) database. In multivariable models, the cross-sectional and longitudinal associations of ARHL with CSF beta-amyloid (A beta) and tau measurements, brain A beta load, and cortical structural measures were explored. ARHL was associated with higher CSF levels of tau (p < 0.001) or ptau181 (p < 0.05) at baseline as well as faster elevation rates of these two types of biomarkers (p < 0.05). Although the baseline volume/thickness of hippocampus (p < 0.05) and entorhinal cortex (p < 0.0005) were higher in individuals with ARHL, these two regions (p < 0.01 for hippocampus, p < 0.05 for entorhinal cortex) displayed significantly accelerated atrophy in individuals with ARHL. No association of ARHL with CSF or brain A beta levels was found. Subgroup analyses indicated that the above effects of ARHL were more significant in non-demented stage. Age-related hearing loss was associated with elevated cerebrospinal fluid tau levels and atrophy of entorhinal cortex.
[1]Ocean Univ China, Coll Med & Pharmaceut, Qingdao Municipal Hosp, Dept Neurol, Qingdao, Shandong, Peoples R China;
[2]Harvard Med Sch, Massachusetts Gen Hosp, Mass Gen Inst Neurodegenerat Dis MIND, Genet & Aging Res Unit,Dept Neurol, Boston, MA 02114 USA;
[3]Qingdao Univ, Qingdao Municipal Hosp, Dept Neurol, Qingdao, Shandong, Peoples R China;
[4]Qingdao Municipal Hosp, Clin Res Ctr, Qingdao, Shandong, Peoples R China;
[5]Fudan Univ, Shanghai Med Coll, Huashan Hosp, Dept Neurol, Shanghai, Peoples R China;
[6]Fudan Univ, Shanghai Med Coll, Huashan Hosp, Inst Neurol, Shanghai, Peoples R China
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