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HNRNPAB Induces Epithelial-Mesenchymal Transition and Promotes Metastasis of Hepatocellular Carcinoma by Transcriptionally Activating SNAIL 期刊论文

编号：

02e23552-a2c2-4bf1-8f8a-934b7acb2209
作者：

Zhou, ZhengJun^[1,2];Dai, Zhi(代智)^[1,2]Zhou, ShaoLai(周少来)^[1,2]Hu, ZhiQiang(胡志强)^[1,2]Chen, Qing^[1,2];Zhao, YiMing^[1,2];Shi, YingHong(史颖弘)^[1,2]Gao, Qiang(高强)^[1,2]Wu, WeiZhong^[1,2];Qiu, ShuangJian(邱双健)^[1,2]Zhou, Jian(周俭)^[1,2,3]Fan, Jia(樊嘉)*^[1,2,3]
语种：

English
期刊：

CANCER RESEARCH ISSN：0008-5472 2014 年 74 卷 10 期 (2750 - 2762) ; MAY 15
收录：
摘要：

Expression of heterogeneous nuclear ribonucleoprotein AB (HNRNPAB) has been reported to be dysregulated in tumors, but its specific contributions to tumor formation and progression are not fully understood. Here, we demonstrate that HNRNPAB is overexpressed in highly metastatic cells and tumor tissues from patients with hepatocellular carcinoma (HCC) with recurrence. We found that HNRNPAB overexpression promoted epithelial-mesenchymal transition (EMT) in a manner associated with HCC metastasis in vitro and in vivo. RNA interference-mediated silencing of the EMT factor SNAIL attenuated HNRNPAB-enhanced cell invasion in vitro and lung metastasis in vivo. Mechanistically, HNRNPAB acted to transactivate SNAIL1 transcription, which in turn inhibited transcription of the pivotal SNAIL target gene E-cadherin. Overexpression of HNRNPAB in HCC samples correlated with higher SNAIL levels, shorter overall survival, and higher tumor recurrence. HNRNPAB overexpression, alone or in combination with SNAIL, was found to be a significant independent risk factor for recurrence and survival after curative resection. In conclusion, our findings define HNRNPAB as an activator of EMT and metastasis in HCC that predicts poor clinical outcomes. (C)2014 AACR.
推荐引用方式
GB/T 7714：

Zhou Zheng-Jun,Dai Zhi,Zhou Shao-Lai, et al. HNRNPAB Induces Epithelial-Mesenchymal Transition and Promotes Metastasis of Hepatocellular Carcinoma by Transcriptionally Activating SNAIL [J].CANCER RESEARCH,2014,74(10):2750-2762.
APA：

Zhou Zheng-Jun,Dai Zhi,Zhou Shao-Lai,Hu Zhi-Qiang,&Fan Jia.(2014).HNRNPAB Induces Epithelial-Mesenchymal Transition and Promotes Metastasis of Hepatocellular Carcinoma by Transcriptionally Activating SNAIL .CANCER RESEARCH,74(10):2750-2762.
MLA：

Zhou Zheng-Jun, et al. "HNRNPAB Induces Epithelial-Mesenchymal Transition and Promotes Metastasis of Hepatocellular Carcinoma by Transcriptionally Activating SNAIL" .CANCER RESEARCH 74,10(2014):2750-2762.

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