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Overexpression of YTHDF1 is associated with poor prognosis in patients with hepatocellular carcinoma 期刊论文

编号：

048bcea5-4c20-462a-94c2-5a43a509d16f
作者：

Zhao, Xianguang^[1];Chen, Yang(陈阳)^[2]Mao, Qiqi(毛奇琦)^[1]Jiang, Xiaoyun(蒋晓芸)^[3]Jiang, Weiru(蒋蔚茹)^[3]Chen, Jiajie^[1];Xu, Weijia(徐蔚佳)^[1]Zhong, Liang(钟良)^[3]Sun, Xu(孙旭)*^[3]
语种：

English
期刊：

CANCER BIOMARKERS ISSN：1574-0153 2018 年 21 卷 4 期 (859 - 868)
收录：
关键词：

YTHDF1 HCC m6A prognostic biomarker
摘要：

In China, hepatocellular carcinoma (HCC) is the most commonly diagnosed cancer and the leading cause of cancer death in men, followed by lung and stomach cancer. There was an urgent need to identify novel prognostic biomarkers for HCC. We explored the expression pattern of m6A related proteins in HCC tissues by using TCGA in this study. We found that the m6A 'reader' YTHDF1 was significantly upregulated in HCC and was positive correlated with pathology stage. Kaplan-Meier analysis showed that Lower YTHDF1 expression level was associated with better survival of HCC patients. Furthermore, we performed GO and KEGG pathway analysis of YTHDF1 co-expressed genes and found YTHDF1 played an important role in regulating HCC cell cycle progression and metabolism. We believed that this study will provide a potential new therapeutic and prognostic target for HCC.
推荐引用方式
GB/T 7714：

Zhao Xianguang,Chen Yang,Mao Qiqi, et al. Overexpression of YTHDF1 is associated with poor prognosis in patients with hepatocellular carcinoma [J].CANCER BIOMARKERS,2018,21(4):859-868.
APA：

Zhao Xianguang,Chen Yang,Mao Qiqi,Jiang Xiaoyun,&Sun Xu.(2018).Overexpression of YTHDF1 is associated with poor prognosis in patients with hepatocellular carcinoma .CANCER BIOMARKERS,21(4):859-868.
MLA：

Zhao Xianguang, et al. "Overexpression of YTHDF1 is associated with poor prognosis in patients with hepatocellular carcinoma" .CANCER BIOMARKERS 21,4(2018):859-868.

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