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Intranasal Administration of Chitosan Against Influenza A (H7N9) Virus Infection in a Mouse Model 期刊论文

编号：

04a17439-2def-4fc5-a28d-ef3e70da6986
作者：

Zheng, Mei^[1];Qu, Di(瞿涤)^[2]Wang, Haiming^[1];Sun, Zhiping^[2];Liu, Xueying^[1];Chen, Jianjun^[3];Li, Changgui^[4,5];Li, Xuguang^[6];Chen, Ze^[1,7];
语种：

English
期刊：

SCIENTIFIC REPORTS ISSN：2045-2322 2016 年 6 卷 ; JUN 29
收录：
摘要：

Influenza virus evolves constantly in an unpredictable fashion, making it necessary to vaccinate people annually for effective prevention and control of influenza. In general, however, during the first wave of an influenza outbreak caused by a newly emerging virus strain, influenza morbidity and mortality have been observed to rise sharply due to the lack of a matching vaccine. This necessitates the exploration of novel intervention approaches, particularly those prophylactic or therapeutic agents that have a broad range of antiviral activities and are also proven to be non-toxic. Here, we reported that stimulation of the innate immune system by intranasal administration of chitosan as a single agent was sufficient to completely protect BALB/c mice from lethal infection by H7N9 virus, a newly emerged viral strain that is highly pathogenic to humans. Remarkably, animals could still be protected against lethal challenge by H7N9 (10xLD(50)), even ten days after the intranasal chitosan administration. The significantly enhanced infiltration of leukocytes in the bronchoalveolar lavage and elevated levels of proinflammatory cytokines in the bronchia/lung tissues revealed the potent activation of mucosal immune responses by intranasally delivered chitosan. We also observed that chitosan can protect mice from three other virus strains. The marked breadth and magnitude of protection against diverse viral strains makes chitosan an attractive candidate as a universal anti-influenza agent.
推荐引用方式
GB/T 7714：

Zheng Mei,Qu Di,Wang Haiming, et al. Intranasal Administration of Chitosan Against Influenza A (H7N9) Virus Infection in a Mouse Model [J].SCIENTIFIC REPORTS,2016,6.
APA：

Zheng Mei,Qu Di,Wang Haiming,Sun Zhiping,&Chen Ze.(2016).Intranasal Administration of Chitosan Against Influenza A (H7N9) Virus Infection in a Mouse Model .SCIENTIFIC REPORTS,6.
MLA：

Zheng Mei, et al. "Intranasal Administration of Chitosan Against Influenza A (H7N9) Virus Infection in a Mouse Model" .SCIENTIFIC REPORTS 6(2016).

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