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Polymorphic CAG/CAA repeat length in the AIB1/SRC-3 gene and prostate cancer risk: A population-based case-control study  期刊论文  

  • 编号:
    04c66ad6-4c1e-4108-aeb4-701dd3767d90
  • 作者:
    Hsing, Ann[0][1] Chokkalingam, Anand P.[1][2] Gao, Yutang[2][3] Wu, Guan[3][4] Wang, Xin[4][5] Deng, Jie[5][6] Cheng, Jiaorong[6][7] Sesterhenn, Isabell A.[7][8] Mostofi, Fathollah Kash[8][9] Chiang, Tzuying[9][5] Chen, YuhLing[10][10] Stanczyk, Frank Z.[11][11] Chang, Chawnshang[12][5]
  • 地址:

    [1]Stanford University,Palo Alto,United States

    [2]UC Berkeley, School of Public Health,Berkeley,United States

    [3]Shanghai Jiaotong University, Department of Epidemiology,Shanghai,China

    [4]University of Rochester Medical Center, Department of Urology,Rochester,United States

    [5]University of Rochester Medical Center, Department of Pathology,Rochester,United States

    [6]Chinese Academy of Agricultural Sciences, Institute of Vegetables and Flowers,Beijing,China

    [7]Medical Center of Fudan University, Shanghai Cancer Institute,Shanghai,China

    [8]Joint Pathology Center, Department of Genitourinary Pathology,Silver Spring,United States

    [9]Armed Forces Institute of Pathology, Department of Genitourinary Pathology,Washington,United States

    [10]National Cheng Kung University, Institute of Basic Medical Sciences,Tainan,Taiwan

    [11]Keck School of Medicine of USC, Department of Obstetrics and Gynecology,Los Angeles,United States

  • 语种:
    英文
  • 期刊:
    Cancer Epidemiology Biomarkers and Prevention ISSN:1055-9965 2002 年 11 卷 4 期 (337 - 341)
  • 收录:
  • 摘要:

    In an earlier report, we showed that a shorter CAG repeat length in the androgen receptor (AR) gene is associated with an increased risk of prostate cancer in China, the population with the lowest reported prostate cancer incidence in the world. Because AR coactivators enhance transactivation of AR, in this report we evaluated the relationship of a CAG/CAA repeat length polymorphism in the AIB1/SRC-3 gene (amplified in breast cancer gene 1, a steroid receptor coactivator and an AR coactivator) with prostate cancer risk in a population-based case-control study in China. Genomic DNA from 189 prostate cancer patients and 301 healthy controls was used for the PCR-based assay. The AIB1/SRC-3 CAG/CAA repeat length ranged from 24 to 32, with the most common repeat length being 29. Homozygous 29/29 and heterozygous 28/29 were the most common genotypes, with 44 and 30% of the controls harboring these genotypes, respectively. Relative to subjects homozygous for 29 CAG/CAA repeats (29/29 genotype), individuals with the <29/29 genotype had a nonsignificant 31% increased risk [odds ratio (OR), 1.31; 95% confidence interval (CI), 0.87-1.97], whereas those homozygous for the <29 allele had a significant 81% excess risk (OR, 1.81; 95% CI, 1.00-3.28). The combined effect of CAG repeat lengths in the AR and AIB1/SRC-3 genes was also evaluated. Relative to men with both the 29/29 genotype of the AIB1/SRC-3 gene and a long CAG repeat length (≥23) in the AR gene, those with both the <29/<29 AIB1/SRC-3 genotype and a short CAG repeat length in the AR gene (<23) had a 2.8-fold risk (OR, 2.78; 95% CI, 1.24-6.26). Together, our data indicate that the CAG/CAA repeat length in the AIB1/SRC-3 gene may be associated with prostate cancer risk in Chinese men and that the combination of CAG/CAA repeat lengths in both the AIB1/SRC-3 and AR genes may provide a useful marker for clinically significant prostate cancer. Expanded studies in other populations are needed to confirm this association and the combined effect of AIBI/SRC-3 and other hormone-related genes in prostate cancer etiology.

  • 推荐引用方式
    GB/T 7714:
    Hsing Ann/7004413686[0],Chokkalingam Anand P./6603383936[1],Gao Yutang/34770682500[2], et al. Polymorphic CAG/CAA repeat length in the AIB1/SRC-3 gene and prostate cancer risk: A population-based case-control study [J].Cancer Epidemiology Biomarkers and Prevention,2002,11(4):337-341.
  • APA:
    Hsing Ann/7004413686[0],Chokkalingam Anand P./6603383936[1],Gao Yutang/34770682500[2],Wu Guan/36109549600[3],&Chang Chawnshang/56743702600[12].(2002).Polymorphic CAG/CAA repeat length in the AIB1/SRC-3 gene and prostate cancer risk: A population-based case-control study .Cancer Epidemiology Biomarkers and Prevention,11(4):337-341.
  • MLA:
    Hsing Ann/7004413686[0], et al. "Polymorphic CAG/CAA repeat length in the AIB1/SRC-3 gene and prostate cancer risk: A population-based case-control study" .Cancer Epidemiology Biomarkers and Prevention 11,4(2002):337-341.
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