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Clinical Immunophenotype at Disease Onset in Previously Healthy Patients With Cryptococcal Meningitis 期刊论文

编号：

0555423d-7406-494a-b321-0f0889d74bd8
作者：

Xu, Lie(徐烈)#^[1]Huang, Qin(黄琴)^[1]Lin, JinRan(林尽染)^[4]Zhu, CuiYun(朱翠云)^[1]Li, XinHua^[5];Ye, ShanKe^[1];Zhu, AiHong^[1];Chen, DaiHong^[2];Zhang, ChengFeng(张成锋)*^[4]Chen, Liang(陈良)*^[3]Ling, Yun(凌云)*^[1]
语种：

English
期刊：

MEDICINE ISSN：0025-7974 2016 年 95 卷 6 期 ; FEB
收录：
摘要：

Cryptococcal meningitis (CM) is a global disease with significant morbidity and mortality. Although low peripheral blood cluster of differentiation 4 (CD4)(+) cell counts are found to be related to a high burden of cryptococcus in HIV-infected patients, little is known about possible immune defects in previously healthy patients (PHPs). We performed a retrospective study of 41 CM patients treated from January 2005 to December 2014 who did not have HIV-infection. There were 33 PHPs and 8 not previously healthy patients (non-PHPs). We analyzed clinical test data pertaining to peripheral blood T cells, antibodies, inflammation markers, and cerebral spinal fluid (CSF) completed during the disease onset phase and 5 years following diagnosis. PHPs had significantly higher counts of cluster of differentiation 3 (CD3)(+), cluster of differentiation 4 (CD4)(+), and cluster of differentiation 45 (CD45)(+) cells, and lower percentages of CD8(+) cells than non-PHPs (P < 0.05). Measurements of inflammatory markers and immunoglobulin in blood were comparable except for lower immunoglobulin A (IgA) levels in non-PHPs (P = 0.0410). Examination of CSF revealed lower white blood cell (WBC) counts in non-PHPs. Five-year mortality in PHPs was higher than in non-PHPs (22.0% vs 12.5%) but this was not statistically significant (P > 0.05). Multivariate analysis revealed that higher immunoglobulin G (IgG) levels in serum during disease onset may be an independent predictor of mortality (P = 0.015). In conclusion, PHPs demonstrate an immunophenotype that is distinct from that of non-PHPs, leading to an improved understanding of the immunology of cryptococcal meningitis.
推荐引用方式
GB/T 7714：

Xu Lie,Huang Qin,Lin Jin-Ran, et al. Clinical Immunophenotype at Disease Onset in Previously Healthy Patients With Cryptococcal Meningitis [J].MEDICINE,2016,95(6).
APA：

Xu Lie,Huang Qin,Lin Jin-Ran,Zhu Cui-Yun,&Ling Yun.(2016).Clinical Immunophenotype at Disease Onset in Previously Healthy Patients With Cryptococcal Meningitis .MEDICINE,95(6).
MLA：

Xu Lie, et al. "Clinical Immunophenotype at Disease Onset in Previously Healthy Patients With Cryptococcal Meningitis" .MEDICINE 95,6(2016).

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