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A Comparative Study of Hollow Copper Sulfide Nanoparticles and Hollow Gold Nanospheres on Degradability and Toxicity 期刊论文

编号：

05c30795-aa9b-471e-8b68-22048e5ac0dd
作者：

Guo, Liangran^[1];Panderi, Irene^[2,4];Yan, Daisy D.^[1];Szulak, Kevin^[1];Li, Yajuan^[1];Chen, YiTzai^[1];Ma, Hang^[1];Niesen, Daniel B.^[1];Seeram, Navindra^[1];Ahmed, Aftab^[1];Yan, Bingfang^[1];Pantazatos, Dionysios^[2,3];Lu, Wei(陆伟)^[1,5]
语种：

English
期刊：

ACS NANO ISSN：1936-0851 2013 年 7 卷 10 期 (8780 - 8793) ; OCT
收录：
关键词：

hollow CuS nanoparticles (HCuSNPs) hollow gold nanospheres (HAuNS) degradability toxicity matrix-assisted laser desorption ionization-time-of-flight imaging mass spectrometry (MALDI-TOF IMS)
摘要：

Gold and copper nanoparticles have been widely investigated for photothermal therapy of cancer. However, degradability and toxicity of these nanoparticles remain concerns. Here, we compare hollow CuS nanoparticles (HCuSNPs) with hollow gold nanospheres (HAuNS) in similar particle sizes and morphology following intravenous administration to mice. The injected pegylated HCuSNPs (PEG-HCuSNPs) are eliminated through both hepatobiliary (67 percentage of injected dose, %ID) and renal (23 %ID) excretion within one month postinjection. By contrast, 3.98 %ID of Au Is excreted from liver and kidney within one month after iv injection of pegylated HAuNS (PEG-HAuNS). Comparatively, PEG-HAuNS are almost nonmetabolizable, while PEG-HCuSNPs are considered biodegradable nanoparticles. PEG-HCuSNPs do not show significant toxicity by histological or blood chemistry analysis. Principal component analysis and 2-D peak distribution plots of data from matrix-assisted laser desorption ionization-time-of-flight imaging mass spectrometry (MALDI-TOF IMS) of liver tissues demonstrated a reversible change in the proteomic profile in mice receiving PEG-HCuSNPs. This is attributed to slow dissociation of Cu ion from CuS nanoparticles along with effective Cu elimination for maintaining homeostasis. Nonetheless, an irreversible change in the proteomic profile is observed in the liver from mice receiving PEG-HAuNS by analysis of MALDI-TOF IMS data, probably due to the nonmetabolizability of Au. This finding correlates with the elevated serum lactate dehydrogenase at 3 months after PEG-HAuNS Injection, indicating potential long-term toxicity. The comparative results between the two types of nanoparticles will advance the development of HCuSNPs as a new class of biodegradable inorganic nanomaterials for photothermal therapy.
推荐引用方式
GB/T 7714：

Guo Liangran,Panderi Irene,Yan Daisy D., et al. A Comparative Study of Hollow Copper Sulfide Nanoparticles and Hollow Gold Nanospheres on Degradability and Toxicity [J].ACS NANO,2013,7(10):8780-8793.
APA：

Guo Liangran,Panderi Irene,Yan Daisy D.,Szulak Kevin,&Lu Wei.(2013).A Comparative Study of Hollow Copper Sulfide Nanoparticles and Hollow Gold Nanospheres on Degradability and Toxicity .ACS NANO,7(10):8780-8793.
MLA：

Guo Liangran, et al. "A Comparative Study of Hollow Copper Sulfide Nanoparticles and Hollow Gold Nanospheres on Degradability and Toxicity" .ACS NANO 7,10(2013):8780-8793.

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