SF/gelatin blend nanofibers matrices as scaffolds were fabricated successfully via electrospinning with different weight ratio in formic acid, by the formation of intermolecular hydrogen bonds and the transformation of SF microstructure, which afforded scaffolds excellent mechanical properties. Comparing with the SF nanofibers scaffolds, the breaking tenacity of blend nanofiber scaffolds increased from 0.95 N/mm(2) up to 1.60 N/mm(2), average fiber diameter was 89.2nm, specific elongation was 7.6%, the porosity was 87%, the pore diameter was 142nm. MTT, H&E stain and SEM results showed, by addition of gelatin, the adhesion, spreading and proliferation of human umbilic vein endothelium cells (ECV304) and mouse fibroblasts (L929) on the SF/gelatin nanofibers scaffolds were definitely better than the SF nanofiber scaffolds, which showed that the SF/gelatin blend nanofiber matrices met the requirements :For the scaffolds and may be a good candidate for blood vessel engineering scaffolds.
收起[1]Suzhou Univ, Coll Mat Engn, Suzhou 215021, Peoples R China.
[2]Nantong Text Vocat Technol Coll, Dept Text, Nantong 226007, Peoples R China.
[3]Fudan Univ, Zhongshan Hosp, Dept Vasc Surg, Shanghai 200032, Peoples R China.
(8.0+极速模式)