Atopic dermatitis (AD) is the most common chronic inflammatory skin disease in Chinese pediatric patients. To date, the genetic susceptibility to AD in this population has not been fully clarified. Three single nucleotide polymorphisms have previously been associated with AD in Europeans, rs2897442 (KIF3A), rs479844 (OVOL1) and rs2164983 (ACTL9). To verify the correlation between AD and these three SNPs in the Chinese pediatric population, we conducted a case-control study including 235 pediatric patients with AD and 200 health controls. We confirmed the correlation between rs2897442 and rs479844 and AD in this population at both the genotype and allele levels. Statistical analysis showed that the C allele of rs2897442 is associated with an increased risk of developing AD, while the A allele of rs479844 is associated with a reduced risk. No correlation between rs2164983 and AD was identified. Our study indicates that KIF3A and OVOL1 are involved in the development of AD in the Chinese pediatric population. (C) 2015 Elsevier B.V. All rights reserved.
[1]Fudan Univ, Huashan Hosp, Dept Lab Med, Shanghai Med Sch, Shanghai 200040, Peoples R China.
[2]Fudan Univ, Huashan Hosp, Dept Dermatol, Shanghai Med Sch, Shanghai 200040, Peoples R China.
[3]Fudan Univ, Childrens Hosp, Dept Microbiol, Shanghai Med Sch, Shanghai 200040, Peoples R China.
[4]Fudan Univ, Huashan Hosp, Dept Dermatol, Cent Lab, Shanghai 200040, Peoples R China.
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