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GABA(A) Receptor Deficits Predict Recovery in Patients With Disorders of Consciousness: A Preliminary Multimodal [C-11]Flumazenil PET and fMRI Study 期刊论文

编号：

075adda2-152d-4a62-95f6-a97a8f6d63fa
作者：

Qin, Pengmin^[1,2,3];Wu, Xuehai(吴雪海)^[4]Duncan, Niall W.^[1,2,3,5];Bao, Weiqi^[6];Tang, Weijun(汤伟军)^[7]Zhang, Zhengwei^[6];Hu, Jin(胡锦)^[4]Jin, Yi(金毅)^[4]Wu, Xing(吴惺)^[4]Gao, Liang(高亮)^[4]Lu, Lu^[8];Guan, Yihui^[6];Lane, Timothy^[2,3];Huang, Zirui^[2];Bodien, Yelena G.^[9];Giacino, Joseph T.^[9];Mao, Ying(毛颖)^[4]Northoff, Georg^[1,2,3,5,10];
语种：

English
期刊：

HUMAN BRAIN MAPPING ISSN：1065-9471 2015 年 36 卷 10 期 (3867 - 3877) ; OCT
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关键词：

vegetative state minimally conscious state functional connectivity unresponsive wakefulness syndrome Zolpidem salience network default-mode network executive-control network
摘要：

Objectives: Disorders of consciousness (DoC)-that is, unresponsive wakefulness syndrome/vegetative state and minimally conscious state-are debilitating conditions for which no reliable markers of consciousness recovery have yet been identified. Evidence points to the GABAergic system being altered in DoC, making it a potential target as such a marker. Experimental design: In our preliminary study, we used [C-11]Flumazenil positron emission tomography to establish global GABA(A) receptor binding potential values and the local-to-global (LTG) ratio of these for specific regions. These values were then compared between DoC patients and healthy controls. In addition, they were correlated with behavioral improvements for the patients between the time of scanning and 3 months later. Functional magnetic resonance imaging resting-state functional connectivity was also calculated and the same comparisons made. Principal observations: lobal GABA(A) receptor binding was reduced in DoC, as was the LTG ratio in specifically the supragenual anterior cingulate. Both of these measures correlated with behavioral improvement after 3 months. In contrast to these measures of GABA(A) receptor binding, functional connectivity did not correlate with behavioral improvement. Conclusions: Our preliminary findings point toward GABA(A) receptor binding being a marker of consciousness recovery in DoC. (C) 2015 Wiley Periodicals, Inc.
推荐引用方式
GB/T 7714：

Qin Pengmin,Wu Xuehai,Duncan Niall W., et al. GABA(A) Receptor Deficits Predict Recovery in Patients With Disorders of Consciousness: A Preliminary Multimodal [C-11]Flumazenil PET and fMRI Study [J].HUMAN BRAIN MAPPING,2015,36(10):3867-3877.
APA：

Qin Pengmin,Wu Xuehai,Duncan Niall W.,Bao Weiqi,&Northoff Georg.(2015).GABA(A) Receptor Deficits Predict Recovery in Patients With Disorders of Consciousness: A Preliminary Multimodal [C-11]Flumazenil PET and fMRI Study .HUMAN BRAIN MAPPING,36(10):3867-3877.
MLA：

Qin Pengmin, et al. "GABA(A) Receptor Deficits Predict Recovery in Patients With Disorders of Consciousness: A Preliminary Multimodal [C-11]Flumazenil PET and fMRI Study" .HUMAN BRAIN MAPPING 36,10(2015):3867-3877.

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