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Efficacy of antibody-based therapies against Middle East respiratory syndrome coronavirus (MERS-CoV) in common marmosets 期刊论文

编号：

084a85c5-834a-4d0a-a297-e7b429597292
作者：

van Doremalen, Neeltje^[1];Falzarano, Darryl^[2,6];Ying, Tianlei(应天雷)^[3,7,8,9]de Wit, Emmie^[2];Bushmaker, Trenton^[1];Feldmann, Friederike^[4];Okumura, Atsushi^[2,5];Wang, Yanping^[3];Scott, Dana P.^[4];Hanley, Patrick W.^[4];Feldmann, Heinz^[2];Dimitrov, Dimiter S.^[3];Munster, Vincent J.^[1];
语种：

English
期刊：

ANTIVIRAL RESEARCH ISSN：0166-3542 2017 年 143 卷 (30 - 37) ; JUL
收录：
关键词：

MERS-CoV Treatment Monoclonal antibodies Hyperimmune plasma Common marmoset Immunotherapy
摘要：

Cases of Middle East respiratory syndrome coronavirus (MERS-CoV) continue to be identified and with a lack of effective clinical treatment and no preventative strategies, treatment using convalescent plasma or monoclonal antibodies (mAbs) is a potential quick route to an intervention. Passive immunotherapy via either convalescent plasma or mAbs has proven to be effective for other infectious agents. Following infection with MERS-CoV, common marmosets were treated with high titer hyperimmune plasma or the mAb m336, at 6 and 48 h post inoculation. Both treatments reduced signs of clinical disease, but reduction in viral loads in the respiratory tract were only found in the hyperimmune plasma group. A decrease in gross pathology was found only in the mAb-treated group, but no histological differences were observed between treated and control animals. While both hyperimmune plasma and the m336 treatments reduced the severity of disease in the common marmoset, neither treatment resulted in full protection against disease. (C) 2017 Published by Elsevier B.V.
推荐引用方式
GB/T 7714：

van Doremalen Neeltje,Falzarano Darryl,Ying Tianlei, et al. Efficacy of antibody-based therapies against Middle East respiratory syndrome coronavirus (MERS-CoV) in common marmosets [J].ANTIVIRAL RESEARCH,2017,143:30-37.
APA：

van Doremalen Neeltje,Falzarano Darryl,Ying Tianlei,de Wit Emmie,&Munster Vincent J..(2017).Efficacy of antibody-based therapies against Middle East respiratory syndrome coronavirus (MERS-CoV) in common marmosets .ANTIVIRAL RESEARCH,143:30-37.
MLA：

van Doremalen Neeltje, et al. "Efficacy of antibody-based therapies against Middle East respiratory syndrome coronavirus (MERS-CoV) in common marmosets" .ANTIVIRAL RESEARCH 143(2017):30-37.

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