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Transdermal microemulsion drug delivery system for impairing male reproductive toxicity and enhancing efficacy of Tripterygium Wilfordii Hook f 期刊论文

编号：

0890b507-54f7-4d55-b2d4-31d8f0436b5d
作者：

Wang, Xiao^[1,2];Xue, Mei^[3];Cu, Jijin^[1,2];Fang, Xiaoling(方晓玲)^[1,2]Sha, Xianyi(沙先谊)^[1,2]
语种：

English
期刊：

FITOTERAPIA ISSN：0367-326X 2012 年 83 卷 4 期 (690 - 698) ; JUN
收录：
关键词：

TWHF Microemulsion Transdermal delivery system Pharmacodynamics Toxicity
摘要：

The present study is trying to produce a transdermal microemulsion drug delivery system (TMDDS) for Tripterygium Wilfordii Hook f. (TWHF) and attempting to solve male reproductive toxicity problem of TWHF. The formulation was optimized by the central composite design with response surface methodology and was decided as 12% oleic acid, 19.7% Labrasol S. 19.7% ethanol and 19.7% Pharmasolve, and 29% water. TMDDS for TWHF had stronger transdermal ability than free TWHF, and TWHF microemulsion significantly inhibited the adjuvant-induced arthritis and at the same time, had preferable anti-inflammatory effect with the long-time administration. Various pharmacodynamics parameters proved that TWHF microemulsion can reduce the male reproductive toxicity and hepatotoxicity of rats. All these suggested that TMDDS could be a suitable delivery system for TWHF. (C) 2012 Elsevier B.V. All rights reserved.
推荐引用方式
GB/T 7714：

Wang Xiao,Xue Mei,Cu Jijin, et al. Transdermal microemulsion drug delivery system for impairing male reproductive toxicity and enhancing efficacy of Tripterygium Wilfordii Hook f [J].FITOTERAPIA,2012,83(4):690-698.
APA：

Wang Xiao,Xue Mei,Cu Jijin,Fang Xiaoling,&Sha Xianyi.(2012).Transdermal microemulsion drug delivery system for impairing male reproductive toxicity and enhancing efficacy of Tripterygium Wilfordii Hook f .FITOTERAPIA,83(4):690-698.
MLA：

Wang Xiao, et al. "Transdermal microemulsion drug delivery system for impairing male reproductive toxicity and enhancing efficacy of Tripterygium Wilfordii Hook f" .FITOTERAPIA 83,4(2012):690-698.

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