首页 / 院系成果 / 成果详情页

The Numerical Predominance and Large Transcriptome Differences of Neutrophils in Peripheral Blood Together Inevitably Account for a Reported Pulmonary Tuberculosis Signature 期刊论文

编号：

0a741b96-0674-42c7-b2f1-3844c125475e
作者：

Wu, Kang(吴康)#^[1,2]Wong, KaWing^[1,2];Deng, WangLong^[3];Zhang, Hao^[4];Li, Jing^[5];Lowrie, Douglas B.^[1,2];Fan, XiaoYong(范小勇)*^[1,2]
语种：

English
期刊：

INTERNATIONAL JOURNAL OF GENOMICS ISSN：2314-436X 2017 年
收录：
摘要：

Previous transcriptomic analysis revealed a 393- transcript signature (PTBsig), which is dominated by interferon inducible genes, in whole blood of pulmonary tuberculosis (PTB) patients. Comparisons with a limited set of interferon- driven genes among separated monocytes, CD4+ T cells, CD8+ T cells, and neutrophils indicated that the signature is due to changes in neutrophils, the overwhelmingly predominant cell type. By extending the analysis to the entire 393 transcripts of PTBsig and by switching the cell proportions between separatedmonocytes, CD4+ T cells, CD8+ T cells, and neutrophils, we create putative PTBsig forwhole blood (pPTB-sig) in which CD4+ or CD8+ T cells or monocytes predominated or in which the cell proportions were unchanged. These putative signatures are then compared to the actual reported PTBsig. We show that, because of their predominance in peripheral blood and their larger transcriptional responses, neutrophils were indeed almost exclusively responsible for PTBsig. We caution that the functional significance of changes in other cell types might escape notice in transcriptome analysis that is based upon whole blood.
推荐引用方式
GB/T 7714：

Wu Kang,Wong Ka-Wing,Deng Wang-Long, et al. The Numerical Predominance and Large Transcriptome Differences of Neutrophils in Peripheral Blood Together Inevitably Account for a Reported Pulmonary Tuberculosis Signature [J].INTERNATIONAL JOURNAL OF GENOMICS,2017.
APA：

Wu Kang,Wong Ka-Wing,Deng Wang-Long,Zhang Hao,&Fan Xiao-Yong.(2017).The Numerical Predominance and Large Transcriptome Differences of Neutrophils in Peripheral Blood Together Inevitably Account for a Reported Pulmonary Tuberculosis Signature .INTERNATIONAL JOURNAL OF GENOMICS.
MLA：

Wu Kang, et al. "The Numerical Predominance and Large Transcriptome Differences of Neutrophils in Peripheral Blood Together Inevitably Account for a Reported Pulmonary Tuberculosis Signature" .INTERNATIONAL JOURNAL OF GENOMICS(2017).

浏览次数：5  下载次数：0

分享到：

浏览次数：5

下载次数：0

打印次数：0