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Effects of Platelet-Rich Plasma on Tissue Expansion in Rabbits 期刊论文

编号：

0aab9b62-389d-4b91-973d-8d908475413d
作者：

Wang Jinming^[1];Liu Caiyue^[1];Wu Baojin(吴包金)^[2]Liu Antang^[1];Zhang Yingfan^[1];Wang Hui^[1];Zhu Lie^[1];Jiang Hua^[1];
语种：

English
期刊：

AESTHETIC PLASTIC SURGERY ISSN：0364-216X 2017 年 41 卷 2 期 (454 - 460) ; APR
收录：
关键词：

Platelet-rich plasma Tissue expansion Vascular endothelial growth factor
摘要：

Background Tissue expansion has been widely applied in clinic practice. However, the expanded skin is always insufficient for clinical use and how to promote tissue expansion is still a challenge. Platelet-rich plasma (PRP) contains multiple tissue growth factors and has been widely utilized in hard- and soft-tissue augmentation. However, its feasibility to promote tissue expansion has not been explored. The purpose of this study was to evaluate the possible effect of PRP in tissue expansion. Methods Tissue expanders were implanted in the dorsal sides of rabbit ears, and the left and right side were for the PRP group and the control group randomly. The PRP group was injected with 1.0 mL of autologous PRP in the expansion skin and the control group with the same volume of saline solution. The expanders were inflated regularly by injecting saline solution under the same pressure. After the inflation phase, the expansion skin was harvested and the inflation volume, gross specimen, and histological characteristics were assayed and evaluated. Results The mean inflation volume of the PRP group was significantly higher than that of the control (p < 0.05). H&E staining of expanded skin sections showed more epidermal cell layers and thicker skin in the PRP group than that in the control group. There were significantly more capillaries in the expanded skin in the PRP group than those from the control group by IHC staining with its marker anti-CD31. A higher level of mRNA expression of VEGF was observed in the PRP group by real-time PCR. Conclusions The present study suggests that PRP plays a pivotal role in tissue expansion and skin proliferation. No Level Assigned This journal requires that authors assign a level of evidence to each article. For a full description of these Evidence-Based Medicine ratings, please refer to the Table of Contents or the online Instructions to Authors.
推荐引用方式
GB/T 7714：

Wang Jinming,Liu Caiyue,Wu Baojin, et al. Effects of Platelet-Rich Plasma on Tissue Expansion in Rabbits [J].AESTHETIC PLASTIC SURGERY,2017,41(2):454-460.
APA：

Wang Jinming,Liu Caiyue,Wu Baojin,Liu Antang,&Jiang Hua.(2017).Effects of Platelet-Rich Plasma on Tissue Expansion in Rabbits .AESTHETIC PLASTIC SURGERY,41(2):454-460.
MLA：

Wang Jinming, et al. "Effects of Platelet-Rich Plasma on Tissue Expansion in Rabbits" .AESTHETIC PLASTIC SURGERY 41,2(2017):454-460.

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