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Overexpression of SCYL1-BP1 stabilizes functional p53 by suppressing MDM2-mediated ubiquitination 期刊论文

编号：

0b74104f-58f1-49ce-b6d2-f26bef452ca9
作者：

Yan, Jing^[1,2] Di, Yujun^[1] Shi, Huili^[1] Rao, Hai^[2] Huo, Keke^[1]
语种：

English
期刊：

FEBS LETTERS ISSN：1873-3468 2010 年 584 卷 20 期 (4319 - 4324) ; OCT 22
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关键词：

SCYL1-BP1 p53 MDM2 Tumorigenicity
摘要：

Previously, we defined SCY1-like 1 binding protein 1 (SCYL1-BP1) to be a substrate of Pirh2 that binds to mouse double minute gene number 2 (MDM2). In the current study, we found that an increase in SCYL1-BP1 protein levels caused a parallel change in the amount of p53 protein due to the inhibition by SCYL-BP1 of MDM2-mediated p53 ubiquitination. SCYL1-BP1 was not able to alter the ubiquitination of p53 by human papillomavirus protein E6, indicating that the effect was specific for MDM2. Increases in the level of SCYL1-BP1 protein in cells led to the greater transcriptional activation of p21 and gadd45, reduced rate of cellular proliferation, increased levels of apoptosis and inhibition of tumorigenicity. Thus, we propose that SCYL1-BP1 is a novel regulator of the MDM2-p53 feedback loop and that it may be a potential tumor suppressor. (C) 2010 Federation of European Biochemical Societies. Published by Elsevier B.V. All rights reserved.
推荐引用方式
GB/T 7714：

Yan Jing,Di Yujun,Shi Huili, et al. Overexpression of SCYL1-BP1 stabilizes functional p53 by suppressing MDM2-mediated ubiquitination [J].FEBS LETTERS,2010,584(20):4319-4324.
APA：

Yan Jing,Di Yujun,Shi Huili,Rao Hai,&Huo Keke.(2010).Overexpression of SCYL1-BP1 stabilizes functional p53 by suppressing MDM2-mediated ubiquitination .FEBS LETTERS,584(20):4319-4324.
MLA：

Yan Jing, et al. "Overexpression of SCYL1-BP1 stabilizes functional p53 by suppressing MDM2-mediated ubiquitination" .FEBS LETTERS 584,20(2010):4319-4324.

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