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Adjuvant chemotherapy increases the prevalence of fat necrosis in immediate free abdominal flap breast reconstruction 期刊论文

编号：

0b87aebc-4b7e-43a2-b9fd-54dfe7780360
作者：

Li, Lin(李琳)#^[1,2]Chen, Ying^[1,2];Chen, Jiaying^[1,2];Chen, Jiajian(陈嘉健)^[1,2]Yang, Benlong(杨犇龙)^[1,2]Li, Junjie^[1,2];Huang, Xiaoyan(黄晓燕)^[1,2]Shen, Zhenzhou(沈镇宙)^[1,2]Shao, Zhimin(邵志敏)^[1,2]Yu, Peirong^[3];Wu, Jiong^[1,2];
语种：

English
期刊：

JOURNAL OF PLASTIC RECONSTRUCTIVE AND AESTHETIC SURGERY ISSN：1748-6815 2014 年 67 卷 4 期 (461 - 467) ; APR
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关键词：

Breast reconstruction Free tissue flap Microsurgery Post-operative complications Fat necrosis Adjuvant chemotherapy Risk factors
摘要：

Background: Fat necrosis is one of the most common complications following free flap breast reconstruction. Although a minor complication, fat necrosis can compromise esthetic results and confuse with cancer recurrence. Perfusion-related factors and postoperative radiotherapy are the known risks. However, the influence of adjuvant chemotherapy on fat necrosis prevalence remains unknown. Methods: Our initial experience of 88 consecutive breast reconstructions with free abdominal flaps was reviewed. The prevalence of fat necrosis was recorded and the risk factors were analyzed using univariate and multivariate logistic regression models. Results: The overall prevalence of fat necrosis was 36.4% in this series. In a multivariate logistic regression model, adjuvant chemotherapy significantly increased the risk of fat necrosis. The relative risk was 4.762 (95% confidence interval (CI), 1.767-12.831; p=0.002). There was no evidence of a specific chemotherapeutic agent causing fat necrosis. The first cycle of adjuvant chemotherapy was frequently delivered earlier in patients with fat necrosis than those without fat necrosis, although this tendency was not statistically significant. Conclusions: Our initial experience with free flap breast reconstruction seems to suggest that chemotherapy may increase the risk of fat necrosis following immediate breast reconstruction. Patients should be fully informed, and the initiation of post-operative chemotherapy may be adjusted accordingly. (C) 2014 Published by Elsevier Ltd on behalf of British Association of Plastic, Reconstructive and Aesthetic Surgeons.
推荐引用方式
GB/T 7714：

Li Lin,Chen Ying,Chen Jiaying, et al. Adjuvant chemotherapy increases the prevalence of fat necrosis in immediate free abdominal flap breast reconstruction [J].JOURNAL OF PLASTIC RECONSTRUCTIVE AND AESTHETIC SURGERY,2014,67(4):461-467.
APA：

Li Lin,Chen Ying,Chen Jiaying,Chen Jiajian,&Wu Jiong.(2014).Adjuvant chemotherapy increases the prevalence of fat necrosis in immediate free abdominal flap breast reconstruction .JOURNAL OF PLASTIC RECONSTRUCTIVE AND AESTHETIC SURGERY,67(4):461-467.
MLA：

Li Lin, et al. "Adjuvant chemotherapy increases the prevalence of fat necrosis in immediate free abdominal flap breast reconstruction" .JOURNAL OF PLASTIC RECONSTRUCTIVE AND AESTHETIC SURGERY 67,4(2014):461-467.

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