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Mycobacterium tuberculosis lineage 4 comprises globally distributed and geographically restricted sublineages  期刊论文  

  • 编号：
    0c1fc697-bdbf-421c-be75-64770920e029
  • 作者：
    Stucki, David[1,2];Brites, Daniela[1,2];Jeljeli, Leila[3,4];Coscolla, Mireia[1,2];Liu, Qingyun[5,6,7];Trauner, Andrej[1,2];Fenner, Lukas[1,2,8];Rutaihwa, Liliana[1,2];Borrell, Sonia[1,2];Luo, Tao[9];Gao, Qian(高谦)[5,6,7]KatoMaeda, Midori[10];Ballif, Marie[1,2,8];Egger, Matthias[8];Macedo, Rita[11];Mardassi, Helmi[4];Moreno, Milagros[12];Tudo Vilanova, Griselda[13];Fyfe, Janet[14];Globan, Maria[14];Thomas, Jackson[15];Jamieson, Frances[16];Guthrie, Jennifer L.[16];AsantePoku, Adwoa[17];YeboahManu, Dorothy[17];Wampande, Eddie[18];Ssengooba, Willy[18,19];Joloba, Moses[18];Boom, W. Henry[20];Basu, Indira[21];Bower, James[21];Saraiva, Margarida[22,23];Vasconcellos, Sidra E. G.[24];Suffys, Philip[24];Koch, Anastasia[25,26];Wilkinson, Robert[25,26,27,28];GailBekker, Linda[25,26];Malla, Bijaya[1,2];Ley, Serej D.[1,2,29];Beck, HansPeter[1,2];de Jong, Bouke C.[30];Toit, Kadri[31];SanchezPadilla, Elisabeth[32];Bonnet, Maryline[32];GilBrusola, Ana[33];Frank, Matthias[34];Beng, Veronique N. Penlap[35];Eisenach, Kathleen[36];Alani, Issam[37];Ndung'u, Perpetual Wangui[38];Revathi, Gunturu[39];Gehre, Florian[30,40];Akter, Suriya[30];Ntoumi, Francine[34,41];StewartIsherwood, Lynsey[42];Ntinginya, Nyanda E.[43];Rachow, Andrea[44,45];Hoelscher, Michael[44,45];Cirillo, Daniela Maria[46];Skenders, Girts[47];Hoffner, Sven[48];Bakonyte, Daiva[49];Stakenas, Petras[49];Diel, Roland[50];Crudu, Valeriu[51];Moldovan, Olga[52];AlHajoj, Sahal[53];Otero, Larissa;Barletta, Francesca[54];Carter, E. Jane[55,56];Diero, Lameck[56];Supply, Philip[57];Comas, Inack[58,59];Niemann, Stefan[3,60];Gagneux, Sebastien[1,2];
  • 语种：
    English
  • 期刊：
    NATURE GENETICS ISSN：1061-4036 2016 年 48 卷 12 期 (1535 - 1543) ; DEC
  • 收录：
     
  • 摘要：

    Generalist and specialist species differ in the breadth of their ecological niches. Little is known about the niche width of obligate human pathogens. Here we analyzed a global collection of Mycobacterium tuberculosis lineage 4 clinical isolates, the most geographically widespread cause of human tuberculosis. We show that lineage 4 comprises globally distributed and geographically restricted sublineages, suggesting a distinction between generalists and specialists. Population genomic analyses showed that, whereas the majority of human T cell epitopes were conserved in all sublineages, the proportion of variable epitopes was higher in generalists. Our data further support a European origin for the most common generalist sublineage. Hence, the global success of lineage 4 reflects distinct strategies adopted by different sublineages and the influence of human migration.

  • 推荐引用方式
    GB/T 7714：
    Stucki David,Brites Daniela,Jeljeli Leila, et al. Mycobacterium tuberculosis lineage 4 comprises globally distributed and geographically restricted sublineages [J].NATURE GENETICS,2016,48(12):1535-1543.
  • APA：
    Stucki David,Brites Daniela,Jeljeli Leila,Coscolla Mireia,&Gagneux Sebastien.(2016).Mycobacterium tuberculosis lineage 4 comprises globally distributed and geographically restricted sublineages .NATURE GENETICS,48(12):1535-1543.
  • MLA：
    Stucki David, et al. "Mycobacterium tuberculosis lineage 4 comprises globally distributed and geographically restricted sublineages" .NATURE GENETICS 48,12(2016):1535-1543.
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