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Evaluation of functional genetic variants for breast cancer risk: Results from the Shanghai breast cancer study 期刊论文

编号：

0c342d22-a64f-4f55-acdf-a84c64778ab7
作者：

Zhang, Ben[0]^[1] BeeghlyFadiel, Alicia[1]^[1] Lü, Wei[2]^[2] Cai, Qiuyin[3]^[1] Xiang, Yongbing[4]^[3] Zheng, Ying[5]^[4] Long, Jirong[6]^[1] Ye, Chuanzhong[7]^[5] Gu, Kai[8]^[6] Shu, Xiaoou[9]^[5] Gao, Yutang[10]^[7] Zheng, Wei[11]^[5]
地址：

[1]Vanderbilt University School of Medicine, Department of Medicine,Nashville,United States
[2]Chinese Academy of Sciences, National Laboratory for Infrared Physics,Beijing,China
[3]Renji Hospital, Department of Epidemiology,Shanghai,China
[4]Huazhong University of Science and Technology, School of Automation,Wuhan,China
[5]Vanderbilt Ingram Cancer Center, Department of Medicine,Nashville,United States
[6]Shanghai Municipal Center for Disease Control and Prevention, Department of Cancer Control and Prevention,Shanghai,China
[7]Medical Center of Fudan University, Shanghai Cancer Institute,Shanghai,China
语种：

英文
期刊：

American Journal of Epidemiology ISSN：0002-9262 2011 年 173 卷 10 期 (1159 - 1170)
收录：
关键词：

breast neoplasms genetic genetics polymorphism sex hormone-binding globulin
摘要：

In previous studies among 1,144 cases and 1,256 controls recruited in stage 1 of the Shanghai Breast Cancer Study (SBCS I; 1996-1998), 18 known or potentially functional single nucleotide polymorphisms (SNPs) in 16 genes were found to be associated with breast cancer risk. The authors evaluated these associations among 1,918 cases and 1,819 controls recruited in stage 2 of the SBCS (SBCS II; 2002-2005) using genetic effect models and subgroup analyses predetermined from SBCS I results. Five SNPs (AHR rs2066853, ATM rs1003623, ESR1 rs2234693, GSTP1 rs1695, and SHBG rs6259) showed generally consistent results in SBCS I and SBCS II and statistically significant associations with breast cancer risk in combined analyses, mostly in subgroups defined by age or menopausal status. Further, the relation between breast cancer risk and SHBG rs6259 was found to vary by body mass index (weight (kg)/height (m)2) (P for interaction = 0.003). The strongest reduction in risk associated with SHBG rs6259 was found for lean (body mass index <23) postmenopausal minor allele carriers (odds ratio = 0.6, 95% confidence interval: 0.5, 0.8; P = 4.6 × 10-4). This biologically plausible and highly significant finding provides strong evidence for a true association among Asian women. This study also highlights the value of gene-environment interaction analyses in evaluating genetic factors for complex diseases. © The Author 2011. Published by Oxford University Press on behalf of the Johns Hopkins Bloomberg School of Public Health. All rights reserved.
推荐引用方式
GB/T 7714：

Zhang Ben/55507060300[0],Beeghly-Fadiel Alicia/24471247700[1],Lü Wei/36077781100[2], et al. Evaluation of functional genetic variants for breast cancer risk: Results from the Shanghai breast cancer study [J].American Journal of Epidemiology,2011,173(10):1159-1170.
APA：

Zhang Ben/55507060300[0],Beeghly-Fadiel Alicia/24471247700[1],Lü Wei/36077781100[2],Cai Qiuyin/7201853606[3],&Zheng Wei/35381589100[11].(2011).Evaluation of functional genetic variants for breast cancer risk: Results from the Shanghai breast cancer study .American Journal of Epidemiology,173(10):1159-1170.
MLA：

Zhang Ben/55507060300[0], et al. "Evaluation of functional genetic variants for breast cancer risk: Results from the Shanghai breast cancer study" .American Journal of Epidemiology 173,10(2011):1159-1170.

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