Although studies using animal models have demonstrated that nonhemodynamic factors, including inflammatory cells and cytokines, contribute to left ventricular hypertrophy (LVH), there is little clinical data to confirm this association. Therefore in the present study, levels of circulating specific types of leukocyte were measured to determine the association between white blood cells and left ventricular mass index (LVMI) in hypertensive patients undergoing anti-hypertensive drug therapy. A total of 144 consecutive hypertensive patients taking anti-hypertensive drug therapy were enrolled in the current study. Subjects were divided into two groups: Those with normal geometry and those with left LVH. Total white blood cells and differentiated subtypes (neutrophils, lymphocytes, monocytes) were counted, and left ventricular end-diastolic diameter, left ventricular posterior wall thickness in diastole and inter-ventricular septal wall thickness in diastole were all measured. Analysis revealed a significant correlation between LVMI and total white blood cell levels (P=0.013). The percentage of LVH in the highest tertile of WBC was increased compared with the middle tertile (P=0.008). Furthermore, a significant correlation between the highest tertile of neutrophil counts and LVH was observed (P=0.039). However, no significant associations between LVMI and monocyte or lymphocyte counts were detected. Therefore, the current study determined that increased total white blood cell and neutrophil subtype counts were associated with LVMI in hypertensive patients undergoing anti-hypertensive drug therapy. They may provide convenient and useful markers for further risk appraisal of LVH caused by nonhemodynamic factors of hypertension.
[1]Fudan Univ, Shanghai Inst Cardiovasc Dis, Zhongshan Hosp, Dept Cardiol, 180 Feng Lin Rd, Shanghai 200032, Peoples R China.
[2]Capital Med Univ, Beijing Friendship Hosp, Dept Cardiol, Beijing 100050, Peoples R China.
[3]Qingdao Univ, Yuhuangding Hosp, Dept Cardiol, Qingdao Med Coll, Yantai 264000, Shandong, Peoples R China.
[4]Three Gorges Univ, Yichang Cent Peoples Hosp, Inst Cardiovasc Dis, Dept Cardiol, Yichang 443003, Hubei, Peoples R China.
[5]Qingdao Univ, Dept Cardiol, Affiliated Hosp, Qingdao 266071, Shandong, Peoples R China.
[6]Gaoan Peoples Hosp, Dept Cardiol, Gaoan 330800, Jiangxi, Peoples R China.
[7]Capital Med Univ, Dept Pharm, Beijing 100054, Peoples R China.
[8]Capital Med Univ, Beijing Anzhen Hosp, Dept Cardiol, 2 Anzhen Rd, Beijing 100029, Peoples R China.
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