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Mll2 Controls Cardiac Lineage Differentiation of Mouse Embryonic Stem Cells by Promoting H3K4me3 Deposition at Cardiac-Specific Genes 期刊论文

编号：

0d1b099a-7f97-4bda-bd78-709190a75d42
作者：

Wan, Xiaoling^[1,2];Liu, Lulu^[1,2];Ding, Xiaodan^[2,3];Zhou, Peipei^[2];Yuan, Xiujie^[2];Zhou, Zhongwen(周仲文)^[4]Hu, Ping^[5];Zhou, Hong^[3];Li, Qiang^[6];Zhang, Shenghai^[7];Xiong, Sidong^[1];Zhang, Yan^[2];
语种：

English
期刊：

STEM CELL REVIEWS AND REPORTS ISSN：1550-8943 2014 年 10 卷 5 期 (643 - 652) ; OCT
收录：
关键词：

Histone methylation Cardiac differentiation Embryonic stem cells
摘要：

Trithorax group (TrxG) proteins play critical roles in transcriptional activation by promoting methylation of histone H3 Lysine 4 (H3K4), but the precise functions of the individual TrxG members during embryonic differentiation are not fully understood. Here we show that Mll2, a TrxG member, is required for proliferation but is dispensable for maintaining the pluripotency of mouse embryonic stem cells (ESCs). In addition, differentiation of ESCs toward mesodermal and endodermal lineages is severely altered and, in particular, the cardiac lineage differentiation of ESCs is completely abolished in the absence of Mll2. Moreover, the expression of core cardiac transcription factors and the levels of H3K4 tri-methylation of these cardiac-specific promoters are significantly decreased by the loss of Mll2. Taken together, our results reveal a critical role for Mll2 in proliferation and cardiac lineage differentiation of mouse ESCs, and provide novel molecular insight into the mechanisms of cardiac development and disease.
推荐引用方式
GB/T 7714：

Wan Xiaoling,Liu Lulu,Ding Xiaodan, et al. Mll2 Controls Cardiac Lineage Differentiation of Mouse Embryonic Stem Cells by Promoting H3K4me3 Deposition at Cardiac-Specific Genes [J].STEM CELL REVIEWS AND REPORTS,2014,10(5):643-652.
APA：

Wan Xiaoling,Liu Lulu,Ding Xiaodan,Zhou Peipei,&Zhang Yan.(2014).Mll2 Controls Cardiac Lineage Differentiation of Mouse Embryonic Stem Cells by Promoting H3K4me3 Deposition at Cardiac-Specific Genes .STEM CELL REVIEWS AND REPORTS,10(5):643-652.
MLA：

Wan Xiaoling, et al. "Mll2 Controls Cardiac Lineage Differentiation of Mouse Embryonic Stem Cells by Promoting H3K4me3 Deposition at Cardiac-Specific Genes" .STEM CELL REVIEWS AND REPORTS 10,5(2014):643-652.

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