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MAPT rs242557 variant is associated with hippocampus tau uptake on F-18-AV-1451 PET in non-demented elders  期刊论文  

  • 编号：
    10a003fd-ee64-48a9-af66-d770ca3d29fc
  • 作者：
    Shen, XueNing#[1,2,3]Miao, Dan[3];Li, JieQiong[3];Tan, ChenChen[3];Cao, XiPeng[4];Tan, Lan[3];Yu, JinTai(郁金泰)*[1,2]Weiner, Michael W.[5];Aisen, Paul[6];Weiner, Michael[5,92];Petersen, Ronald[7];Jack, Clifford R., Jr.[7];Jagust, William[8];Trojanowki, John Q.[9,37,93];Toga, Arthur W.[10];Beckett, Laurel[11];Green, Robert C.[12,28];Saykin, Andrew J.[13];Morris, John[15];Shaw, Leslie M.[9,37,93];Khachaturian, Zaven[16];Sorensen, Greg[17];Carrillo, Maria[18];Kuller, Lew[19];Raichle, Marc[15];Paul, Steven[20];Davies, Peter[22];Fillit, Howard[23];Hefti, Franz[24];Holtzman, David[15,25];Mesulam, M. Marcel[25];Potter, William[26];Snyder, Peter[27];Lilly, Eli;Logovinsky, Veronika[39];Montine, Tom[29];Jimenez, Gustavo[10];Donohue, Michael[10,30];Gessert, Devon[10];Harless, Kelly[10];Salazar, Jennifer[10];Cabrera, Yuliana[10];Walter, Sarah[10];Hergesheimer, Lindsey[10];Harvey, Danielle[11];Bernstein, Matthew[7];Fox, Nick[31];Thompson, Paul[32];Schuff, Norbert[33];DeCArli, Charles[11,74];Borowski, Bret[7];Gunter, Jeff[7];Senjem, Matt[7];Vemuri, Prashanthi[7];Jones, David[7];Kantarci, Kejal[7];Ward, Chad[7];Koeppe, Robert A.[34];Foster, Norm[35];Reiman, Eric M.[36];Chen, Kewei[36];Mathis, Chet[19];Landau, Susan[37,93];Morris, John C.[15];Cairns, Nigel J.[15];Franklin, Erin[15];TaylorReinwald, Lisa[15];Lee, Virginia[37,93];Korecka, Magdalena[37,93];Figurski, Michal[37,93];Crawford, Karen[10];Neu, Scott[10];Foroud, Tatiana M.[13];Potkin, Steven[38];Shen, Li[13];Faber, Kelley[13];Kim, Sungeun[13];Nho, Kwangsik[13];Thal, Lean[30];Thal, Leon[30];Buckholtz, Neil[39];Snyder, Peter J.[27];Albert, Marilyn[20,40];Frank, Richard[40,41];Hsiao, John[39];Quinn, Joseph[42];Silbert, Lisa C.[42];Lind, Betty[42];Kaye, Jeffrey A.[42];Carter, Raina[42];Dolen, Sara[42];Schneider, Lon S.[6];Pawluczyk, Sonia[6];Becerra, Mauricio[6];Teodoro, Liberty[6];Spann, Bryan M.[6];Brewer, James[43];Vanderswag, Helen[43];Fleisher, Adam[36,43];Ziolkowski, Jaimie[34];Heidebrink, Judith L.[34];Lord, Joanne L.[34];Mason, Sara S.[7];Albers, Colleen S.[7];Knopman, David[7];Johnson, Kris[7];VillanuevaMeyer, Javier[44];Pavlik, Valory[44];Pacini, Nathaniel[44];Lamb, Ashley[44];Kass, Joseph S.[44];Doody, Rachelle S.[44];Shibley, Victoria[44];Chowdhury, Munir[44];Rountree, Susan[44];Dang, Mimi[44];Stern, Yaakov[45];Honig, Lawrence S.[45];Bell, Karen L.[45];Yeh, Randy[45];Ances, Beau[15];Winkfield, David[15];Carroll, Maria[15];Oliver, Angela[15];Creech, Mary L.[15];Mintun, Mark A.[15];Schneider, Stacy[15];Marson, Daniel[46];Geldmacher, David[46];Love, Marissa Natelson[46];Griffith, Randall[46];Clark, David[46];Brockington, John[46];Grossman, Hillel[47];Mitsis, Effie[47];Shah, Raj C.[48];Lamar, Melissa[48];Samuels, Patricia[48];Duara, Ranjan[49];GreigCusto, Maria T.[49];Rodriguez, Rosemarie[49];Onyike, Chiadi[40];D'Agostino, Daniel, II[40];Kielb, Stephanie[40];Witbracht, Megan[54];Sadowski, Martin[50];Sheikh, Mohammed O.[50];SingletonGarvin, Jamika[50];Ulysse, Anaztasia[50];Gaikwad, Mrunalini[50];Doraiswamy, P. Murali[51];Petrella, Jeffrey R.[51];James, Olga[51];BorgesNeto, Salvador[51];Wong, Terence Z.[51];Coleman, Edward[51];Karlawish, Jason H.[9];Wolk, David A.[9];Vaishnavi, Sanjeev[9];Clark, Christopher M.[9];Arnold, Steven E.[9];Smith, Charles D.[52];Jicha, Greg[52];Hardy, Peter[52];El Khouli, Riham[52];Oates, Elizabeth[52];Conrad, Gary[52];Lopez, Oscar L.[19];Oakley, MaryAnn[19];Simpson, Donna M.[19];Porsteinsson, Anton P.[53];Martin, Kim[53];Kowalksi, Nancy[53];Keltz, Melanie[53];Goldstein, Bonnie S.[53];Makino, Kelly M.[53];Ismail, M. Saleem[53];Brand, Connie[53];Thai, Gaby[54];Pierce, Aimee[54];Yanez, Beatriz[54];Sosa, Elizabeth[54];Womack, Kyle[55];Mathews, Dana[55];Quiceno, Mary[55];Levey, Allan, I[56];Lah, James J.[56];Cellar, Janet S.[56];Burns, Jeffrey M.[57];Swerdlow, Russell H.[57];Brooks, William M.[57];Woo, Ellen[58];Silverman, Daniel H. S.[58];Teng, Edmond[58];Kremen, Sarah[58];Apostolova, Liana[58];Tingus, Kathleen[58];Lu, Po H.[58];Bartzokis, George[58];GraffRadford, Neill R.[59];Parfitt, Francine[59];PokiWalker, Kim[59];Farlow, Martin R.[13];Hake, Ann Marie[13];Matthews, Brandy R.[13];Brosch, Jared R.[13];Herring, Scott[13];van Dyck, Christopher H.[60];Carson, Richard E.[60];Varma, Pradeep[60];Chertkow, Howard[61];Bergman, Howard[61];Hosein, Chris[61];Black, Sandra[62];Stefanovic, Bojana[62];Heyn, Chris (Chinthaka)[62];Hsiung, GingYuek Robin[63];Mudge, Benita[63];Sossi, Vesna[63];Feldman, Howard[63];Assaly, Michele[63];Finger, Elizabeth[64,87];Pasternack, Stephen[64];Pavlosky, William[64];Rachinsky, Irina[64,87];Drost, Dick[64,87];Kertesz, Andrew[64,87];Bernick, Charles[65];Munic, Donna[65];Mesulam, MarekMarsel[25];Rogalski, Emily[25];Lipowski, Kristine[25];Weintraub, Sandra[25];Bonakdarpour, Borna[25];Kerwin, Diana[25];Wu, ChuangKuo[25];Johnson, Nancy[25];Sadowsky, Carl[66];Villena, Teresa[66];Turner, Raymond Scott[67];Johnson, Kathleen[67];Reynolds, Brigid[67];Sperling, Reisa A.[68];Johnson, Keith A.[68];Marshall, Gad A.[68];Yesavage, Jerome[69];Taylor, Joy L.[69];Chao, Steven[69];Lane, Barton[69];Rosen, Allyson[21,69];Tinklenberg, Jared[69];Zamrini, Edward[70];Belden, Christine M.[70];Sirrel, Sherye A.[70];Kowall, Neil[71];Killiany, Ronald[71];Budson, Andrew E.[71];Norbash, Alexander[71];Johnson, Patricia Lynn[71];Obisesan, Thomas O.[72];Oyonumo, Ntekim E.[72];Allard, Joanne[72];Ogunlana, Olu[72];Lerner, Alan[73];Ogrocki, Paula[73];Tatsuoka, Curtis[73];Fatica, Parianne[73];Fletcher, Evan[74];Maillard, Pauline[74];Olichney, John[74];Carmichael, Owen[74];Kittur, Smita[75];Borrie, Michael[76];Lee, TY[76];Bartha, Rob[76];Johnson, Sterling[77];Asthana, Sanjay[77];Carlsson, Cynthia M.[77];Tariot, Pierre[36];Burke, Anna[36];Hetelle, Joel[36];DeMarco, Kathryn[36];Trncic, Nadira[36];Reeder, Stephanie[36];Bates, Vernice[78];Capote, Horacio[78];Rainka, Michelle[78];Scharre, Douglas W.[79];Kataki, Maria[79];Tarawneh, Rawan[79];Zimmerman, Earl A.[80];Celmins, Dzintra[80];Hart, David[80];Pearlson, Godfrey D.[80,81];Blank, Karen[81];Anderson, Karen[81];Flashman, Laura A.[82];Seltzer, Marc[82];Hynes, Mary L.[82];Santulli, Robert B.[82];Sink, Kaycee M.[83];Yang, Mia[83];Mintz, Akiva[83];Ott, Brian R.[84];Tremont, Geoffrey[84];Daiello, Lori A.[84];Bodge, Courtney[85];Salloway, Stephen[85];Malloy, Paul[85];Correia, Stephen[85];Lee, Athena[85];Rosen, Howard J.[5];Miller, Bruce L.[5];Perry, David[5];Mintzer, Jacobo[86];Spicer, Kenneth[86];Bachman, David[86];Pasternak, Stephen[87];Rogers, John[87];Pomara, Nunzio[88];Hernando, Raymundo[88];Sarrael, Antero[88];Miller, Delwyn D.[89];Smith, Karen Ekstam[89];Koleva, Hristina[89];Nam, Ki Won[89];Shim, Hyungsub[89];Schultz, Susan K.[89];Relkin, Norman[20];Chiang, Gloria[20];Lin, Michael[20];Ravdin, Lisa[20];Smith, Amanda[90];Leach, Christi[90];Raj, Balebail Ashok[90];Fargher, Kristin[90];Neylan, Thomas[5];Grafman, Jordan[91];Friedl, Karl[14];Hayes, Jacqueline[5];Finley, Shannon[5];Householder, Erin[15];Fleischman, Debra[48];Arfanakis, Konstantinos[48];Varon, Daniel[49];Greig, Maria T.[49];Goldstein, Bonnie[53];Martin, Kimberly S.[53];Potkin, Steven G.[54];Preda, Adrian[54];Nguyen, Dana[54];Massoglia, Dino[86];BrawmanMintzer, Olga[86];Martinez, Walter[66];Rosen, Howard[5,21];Behan, Kelly[67];Marshall, Gad[68];Sabbagh, Marwan N.[70];Jacobson, Sandra A.[70];Wolday, Saba[72];Johnson, Sterling C.[77];Fruehling, J. Jay[77];Harding, Sandra[77];Peskind, Elaine R.[29];Petrie, Eric C.[29];Li, Gail[29];Yesavage, Jerome A.[69];Furst, Ansgar J.[69];Mackin, Scott[21];Raman, Rema[6];Drake, Erin[28];Donohue, Mike[10];Shaffer, Elizabeth[10];Nelson, Craig[21];Bickford, David[21];Butters, Meryl[19];Zmuda, Michelle[19];Reyes, Denise[7];Faber, Kelley M.[13];Nudelman, Kelly N.[13];Au, Yiu Ho[21];Scherer, Kelly[21];Catalinotto, Daniel[21];Stark, Samuel[21];Ong, Elise[5,21];Fernandez, Dariella[5,21];
  • 语种：
    英文
  • 期刊：
    AGING-US ISSN：1945-4589 2019 年 11 卷 3 期 (874 - 884) ; FEB 15
  • 收录：
     
  • 关键词：
    tauopathy MAPT hippocampus F-18-AV-1451 PET non-demented Alzheimer's disease
  • 摘要：

    The microtubule-associated protein tau gene (MAPT) rs242557 variant is associated with multiple tauopathies and dementia. This study investigated whether it was correlated with brain tau-PET uptake in non-demented elders. Ninety non-demented elders were identified from the Alzheimer's Disease Neuroimaging Initiative cohort. We compared standardized uptake value ratios (SUVRs) of tau-PET tracer F-18-AV-1451 between rs242557 variant carriers and non-carriers in 25 regions of interest (ROIs). The minor allele A was associated with increased hippocampus F-18-AV-1451 uptake in non-demented elders (left: beta = 0.111, Bonferroni corrected p = 0.035; right: beta = 0.103, Bonferroni corrected p = 0.031). A beta-positive participants (left: beta = 0.206, Bonferroni corrected p = 0.029; right: beta = 0.198, Bonferroni corrected p = 0.035) and APOE epsilon 4 non-carriers (left: beta = 0.140, Bonferroni corrected p = 0.006; right: beta = 0.134, Bonferroni corrected p = 0.004) exhibited approximately the same findings in hippocampus. Considering no obvious associations in other regions, we confirmed the significant correlation of MAPT rs242557 risk variant with increased hippocampus tau deposition in non-demented elders. With higher magnitude signals in the hippocampus that is more likely to be uniquely affected in AD, the tau PET ligand F-18-AV-1451 seemed to possess a specific binding property for AD-like tau pathology.

  • 推荐引用方式
    GB/T 7714：
    Shen Xue-Ning,Miao Dan,Li Jie-Qiong, et al. MAPT rs242557 variant is associated with hippocampus tau uptake on F-18-AV-1451 PET in non-demented elders [J].AGING-US,2019,11(3):874-884.
  • APA：
    Shen Xue-Ning,Miao Dan,Li Jie-Qiong,Tan Chen-Chen,&Fernandez Dariella.(2019).MAPT rs242557 variant is associated with hippocampus tau uptake on F-18-AV-1451 PET in non-demented elders .AGING-US,11(3):874-884.
  • MLA：
    Shen Xue-Ning, et al. "MAPT rs242557 variant is associated with hippocampus tau uptake on F-18-AV-1451 PET in non-demented elders" .AGING-US 11,3(2019):874-884.
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