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An Elevated Peripheral Blood Lymphocyte-to-Monocyte Ratio Predicts Favorable Response and Prognosis in Locally Advanced Breast Cancer following Neoadjuvant Chemotherapy 期刊论文

编号：

151baf3c-468d-4168-9714-0e749e2897f4
作者：

Ni, XiaoJian^[1,2];Zhang, XiaoLan^[4];OuYang, QianWen^[5];Qian, GuoWei^[1,2];Wang, Lei^[1,2];Chen, Sheng(陈盛)^[1,2]Jiang, YiZhou(江一舟)^[1,2]Zuo, WenJia^[1,2];Wu, Jiong^[1,2];Hu, Xin^[1];Shao, ZhiMing^[1,2,3];
语种：

English
期刊：

PLOS ONE ISSN：1932-6203 2014 年 9 卷 11 期 ; NOV 5
收录：
摘要：

Purpose: Neoadjuvant chemotherapy (NCT) is a standard treatment option for locally advanced breast cancer. However, the lack of an efficient method to predict treatment response and patient prognosis hampers the clinical evaluation of patient eligibility for NCT. An elevated lymphocyte-to-monocyte ratio (LMR) has been reported to be associated with a favorable prognosis for certain hematologic malignancies and for nasopharyngeal carcinoma; however, this association has not been investigated in breast cancer. The purpose of this study was to evaluate whether pre-NCT LMR analysis could predict the prognosis of patients with locally advanced breast cancer. Methods: A retrospective cohort of 542 locally advanced breast cancer patients (T3/T4 and/or N2/N3 disease) receiving NCT followed by radical surgery was recruited between May 2002 and August 2011 at the Fudan University Shanghai Cancer Center. Counts for pre-NCT peripheral absolute lymphocytes and monocytes were obtained and used to calculate the LMR. Results: Univariate and multivariate analysis revealed that higher LMR levels (>= 4.25) were significantly associated with favorable DFS (P = 0.009 and P = 0.011, respectively). Additionally, univariate analysis revealed that a higher lymphocyte count (>= 1.5x10(9)/L) showed borderline significance for improved DFS (P = 0.054), while a lower monocyte count (,0.4x10(9)/L) was associated with a significantly better DFS (P = 0.010). Conclusions: An elevated pre-NCT peripheral LMR level was a significantly favorable factor for locally advanced breast cancer patient prognosis. This easily obtained variable may serve as a valuable marker to predict the outcomes of locally advanced breast cancer.
推荐引用方式
GB/T 7714：

Ni Xiao-Jian,Zhang Xiao-Lan,Ou-Yang Qian-Wen, et al. An Elevated Peripheral Blood Lymphocyte-to-Monocyte Ratio Predicts Favorable Response and Prognosis in Locally Advanced Breast Cancer following Neoadjuvant Chemotherapy [J].PLOS ONE,2014,9(11).
APA：

Ni Xiao-Jian,Zhang Xiao-Lan,Ou-Yang Qian-Wen,Qian Guo-Wei,&Shao Zhi-Ming.(2014).An Elevated Peripheral Blood Lymphocyte-to-Monocyte Ratio Predicts Favorable Response and Prognosis in Locally Advanced Breast Cancer following Neoadjuvant Chemotherapy .PLOS ONE,9(11).
MLA：

Ni Xiao-Jian, et al. "An Elevated Peripheral Blood Lymphocyte-to-Monocyte Ratio Predicts Favorable Response and Prognosis in Locally Advanced Breast Cancer following Neoadjuvant Chemotherapy" .PLOS ONE 9,11(2014).

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