首页 / 院系成果 / 成果详情页

"Suspicious" salivary gland FNA: Risk of malignancy and interinstitutional variability 期刊论文

编号：

17aa1f72-deff-4ec4-810e-0f803d7320bc
作者：

Maleki, Zahra^[1] Miller, James Adam^[1] Arab, Seyedeh Elham^[2] Fadda, Guido^[3] Bo, Ping^[4] Wise, Olga^[5] Rossi, Esther Diana^[3] Jhala, Nirag^[2] Ashish, Chandra^[5] Ali, Syed Z.^[1] Wang, He^[2]
语种：

English
期刊：

CANCER CYTOPATHOLOGY ISSN：1934-662X 2018 年 126 卷 2 期 (94 - 100) ; FEB
收录：
关键词：

cytology fine-needle aspiration (FNA) interinstitutional variability risk of malignancy salivary gland suspicious
摘要：

BACKGROUNDFine-needle aspiration (FNA) cytology is well accepted as a safe, reliable, minimally invasive, and cost-effective method for the diagnosis of salivary gland lesions. Salivary gland neoplasms are often difficult to diagnose because of morphologic heterogeneity and a variety of epithelial metaplastic changes. Hence, a number of salivary gland FNA specimens yield indeterminate results. For indeterminate FNA specimens, the suspicious-for-malignancy (SFM) category is used when a specific neoplasm falls short in quantity or quality for the criteria for malignancy. Therefore, the findings are not sufficient for a conclusive diagnosis of malignancy. METHODSThis study was designed to evaluate the risk of malignancy (ROM) for the SFM group at 5 tertiary medical centers worldwide with the aforementioned criteria. Among 12,606 salivary gland FNA cases between 1997 and 2014, 276 (2.2%) were reported to be SFN. Specifically, 114 suspicious cases (41%) had histological follow-up. RESULTSHistological follow-up of the 114 suspicious cases showed 95 malignant tumors indicating a risk of malignancy (ROM) of 83.3%. The ROM varied between 74% and 88% for the 5 participating institutions, and a Fisher's exact test with significance set to p<.05 showed no significant difference in ROM among the institutions (p = .78). CONCLUSIONSOverall, 83.3% of SFM salivary gland FNA specimens turned out to be malignant; there was no significant interinstitutional variability in the ROMs. The SFM category for salivary gland FNA is very homogeneous, and the ROMs are quite similar worldwide. Cancer Cytopathol 2018;126:94-100. (c) 2017 American Cancer Society. The suspicious-for-malignancy category in salivary gland cytology is used for lesions when a specific neoplasm falls short in quantity or quality for the criteria for malignancy. In this study, 83.3% of 114 suspicious-for-malignancy salivary gland fine-needle aspiration specimens are found to be malignant, and there is no significant interinstitutional variability in the risk of malignancy.
推荐引用方式
GB/T 7714：

Maleki Zahra,Miller James Adam,Arab Seyedeh Elham, et al. "Suspicious" salivary gland FNA: Risk of malignancy and interinstitutional variability [J].CANCER CYTOPATHOLOGY,2018,126(2):94-100.
APA：

Maleki Zahra,Miller James Adam,Arab Seyedeh Elham,Fadda Guido,&Wang He.(2018)."Suspicious" salivary gland FNA: Risk of malignancy and interinstitutional variability .CANCER CYTOPATHOLOGY,126(2):94-100.
MLA：

Maleki Zahra, et al. ""Suspicious" salivary gland FNA: Risk of malignancy and interinstitutional variability" .CANCER CYTOPATHOLOGY 126,2(2018):94-100.

浏览次数：3  下载次数：0

分享到：

浏览次数：3

下载次数：0

打印次数：0