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Sentinel hospital surveillance for rotavirus diarrhea in the People's Republic of China, August 2001-July 2003 会议论文

编号：

17edf9a4-493b-4216-9628-475c1eac30f8
作者：

Fang, Zhaoyin[0];Wang, Bei[1];Kilgore, Paul E.[2];Bresee, Joseph S.[3];Zhang, Lijie[4];Sun, Liwei[5];Du, Zengqing[6];Tang, Jingyu[7];Hou, Ancun[8];Shen, Hui[9];Song, Xiaobo[10];Nyambat, Batmunkh[11];Hummelman, Erik G.[12];Xu, Zhiyi[13];Glass, Roger I.M.[14]
作者单位：

Chinese Center for Disease Control and Prevention, Department of Viral Diarrhea,Beijing,China[0];Genentech Incorporated,San Francisco,United States[1];Wayne State University, Eugene Applebaum College of Pharmacy and Health Sciences,Detroit,United States[2];National Center for Immunization and Respiratory Diseases,,United States[3];Yanshan University, Key Laboratory of Advanced Forging and Stamping Technology and Science,Qinhuangdao,China[4];Changchun Children's Hospital,Changchun,China[5];Kunming Children's Hospital,Kunming,China[6];Lulong County Center for Disease Control and Prevention,,China[7];Capital Medical University China, Department of Cardiology,Beijing,China[8];The Center for Disease Control and Prevention of Suzhou Industrial Park,Suzhou,China[9];MaAnShan Steel and Iron Trust Hospital, Department of Pediatrics,,China[10];International Vaccine Institute, Seoul,Seoul,South Korea[11];Centers for Disease Control and Prevention,Atlanta,United States[12];Fudan University, Department of Epidemiology,Shanghai,China[13];National Institutes of Health, Bethesda,Bethesda,United States[14];
会议名称：

Journal of Infectious Diseases
出版信息：

2005 年 192 卷 SUPPL. 1 期 (S94 - S99)
摘要：

China has the second largest birth cohort in the world and the second highest number of deaths due to rotavirus infection. It is also the only country with a licensed rotavirus vaccine. Chinese policy makers now need credible estimates of the burden of rotavirus disease, to decide about vaccine use. From August 2001 through July 2003, prospective hospital-based surveillance for rotavirus diarrhea among children <5 years of age was conducted in 6 sentinel hospitals. Rotavirus isolates were characterized to determine the G and P genotypes circulating during the study. Of 3149 children who were admitted to the hospitals for diarrhea and for whom screening for rotavirus was performed, 1590 (50%) had positive results of an antigen detection assay. Of all episodes of rotavirus diarrhea, 95% occurred during the first 2 years of life. The most common rotavirus strain was P[8]G3 (49% of episodes), and all the common strains were detected, including G9 strains (4% of episodes). Ongoing efforts are under way to more precisely define the burden of rotavirus diarrhea in urban and rural populations, to assess the proportion of episodes that may be due to unusual or emerging strains, and to estimate the economic burden of rotavirus disease. ? 2005 by the Infectious Diseases Society of America. All rights reserved.
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