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Thiamin (Vitamin B1) Biosynthesis and Regulation: A Rich Source of Antimicrobial Drug Targets? 期刊论文

编号：

18b626dd-ade3-4a88-9cb4-ce80bb2677dc
作者：

Du, Qinglin^[1] Wang, Honghai^[2] Xie, Jianping^[1,2]
语种：

English
期刊：

INTERNATIONAL JOURNAL OF BIOLOGICAL SCIENCES ISSN：1449-2288 2011 年 7 卷 1 期 (41 - 52)
收录：
关键词：

thiamin biosynthesis riboswitch Mycobacterium tuberculosis drug targets
摘要：

Drug resistance of pathogens has necessitated the identification of novel targets for antibiotics. Thiamin (vitamin B1) is an essential cofactor for all organisms in its active form thiamin diphosphate (ThDP). Therefore, its metabolic pathways might be one largely untapped source of antibiotics targets. This review describes bacterial thiamin biosynthetic, salvage, and transport pathways. Essential thiamin synthetic enzymes such as Dxs and ThiE are proposed as promising drug targets. The regulation mechanism of thiamin biosynthesis by ThDP riboswitch is also discussed. As drug targets of existing antimicrobial compound pyrithiamin, the ThDP riboswitch might serves as alternative targets for more antibiotics.
推荐引用方式
GB/T 7714：

Du Qinglin,Wang Honghai,Xie Jianping, et al. Thiamin (Vitamin B1) Biosynthesis and Regulation: A Rich Source of Antimicrobial Drug Targets? [J].INTERNATIONAL JOURNAL OF BIOLOGICAL SCIENCES,2011,7(1):41-52.
APA：

Du Qinglin,Wang Honghai,Xie Jianping.(2011).Thiamin (Vitamin B1) Biosynthesis and Regulation: A Rich Source of Antimicrobial Drug Targets? .INTERNATIONAL JOURNAL OF BIOLOGICAL SCIENCES,7(1):41-52.
MLA：

Du Qinglin, et al. "Thiamin (Vitamin B1) Biosynthesis and Regulation: A Rich Source of Antimicrobial Drug Targets?" .INTERNATIONAL JOURNAL OF BIOLOGICAL SCIENCES 7,1(2011):41-52.

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