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Naoxintong attenuates Ischaemia/reperfusion Injury through inhibiting NLRP3 inflammasome activation 期刊论文

编号：

1c1611e2-97a9-4122-ac84-cde6f6420e4f
作者：

Wang, Yaqiong(王雅琼)^[1,2]Yan, Xiaoxiang^[3];Mi, Shouling^[1];Li, Zhang^[4,5];Wang, Yuexiang^[4,5];Zhu, Hong(朱洪)^[1]Sun, Xiaolei(孙晓垒)^[1]Zhao, Buchang^[6];Zhao, Chao^[6];Zou, Yunzeng(邹云增)^[1,7]Hu, Kai(胡凯)^[1]Ding, Xiaoqiang(丁小强)*^[2]Sun, Aijun(孙爱军)*^[1,7]Ge, Junbo(葛均波)*^[1,7]
语种：

English
期刊：

JOURNAL OF CELLULAR AND MOLECULAR MEDICINE ISSN：1582-4934 2017 年 21 卷 1 期 (4 - 12) ; JAN
收录：
关键词：

naoxintong ischaemia reperfusion injury inflammation NLRP3 inflammasome macrophage polarity
摘要：

Naoxintong (NXT) is a Chinese Materia Medica standardized product extracted from 16 various kinds of Chinese traditional herbal medicines including Salvia miltiorrhiza, Angelica sinensis, Astragali Radix. Naoxintong is clinically effective in treating ischaemia heart disease. Nucleotide-binding oligomerization domain-Like Receptor with a Pyrin domain 3 (NLRP3) inflammasome has been critically involved in myocardial ischaemia/reperfusion (I/R) injury. Here, we have been suggested that NXT might attenuate myocardial I/R injury via suppression of NLRP3 inflammasome activation. Male C57BL6 mice were subjected to myocardial I/R injury via 45 min. coronary ligation and release for the indicated times. Naoxintong (0.7 g/kg/day) and PBS were orally administrated for 2 weeks before surgery. Cardiac function assessed by echocardiography was significantly improved in the NXT group compared to PBS group at day 2 after myocardial I/R. NLRP3 inflammasome activation is crucially involved in the initial inflammatory response after myocardial I/R injury, leading to cleaved caspase-1, mature interleukin (IL)-1 production, accompanying by macrophage and neutrophil infiltration. The cardioprotective effect of NXT was associated with a diminished NLRP3 inflammasome activation, decreased pro-inflammatory macrophage (M1 macrophages) and neutrophil infiltration after myocardial I/R injury. In addition, serum levels of IL-1, indicators of NLRP3 inflammasome activation, were also significantly suppressed in the NXT treated group after I/R injury. Naoxintong exerts cardioprotive effects at least partly by suppression of NLRP3 inflammasome activation in this I/R injury model.
推荐引用方式
GB/T 7714：

Wang Yaqiong,Yan Xiaoxiang,Mi Shouling, et al. Naoxintong attenuates Ischaemia/reperfusion Injury through inhibiting NLRP3 inflammasome activation [J].JOURNAL OF CELLULAR AND MOLECULAR MEDICINE,2017,21(1):4-12.
APA：

Wang Yaqiong,Yan Xiaoxiang,Mi Shouling,Li Zhang,&Ge Junbo.(2017).Naoxintong attenuates Ischaemia/reperfusion Injury through inhibiting NLRP3 inflammasome activation .JOURNAL OF CELLULAR AND MOLECULAR MEDICINE,21(1):4-12.
MLA：

Wang Yaqiong, et al. "Naoxintong attenuates Ischaemia/reperfusion Injury through inhibiting NLRP3 inflammasome activation" .JOURNAL OF CELLULAR AND MOLECULAR MEDICINE 21,1(2017):4-12.

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