首页 / 院系成果 / 成果详情页

MicroRNA-638 inhibits cell proliferation, invasion and regulates cell cycle by targeting tetraspanin 1 in human colorectal carcinoma 期刊论文

编号：

1eea80cc-106e-4e85-81b6-ca95fea55a0a
作者：

Zhang, Jiwei^[1];Fei, Bojian^[2];Wang, Qifeng(王奇峰)^[3]Song, Mingxu^[1];Yin, Yuan^[1];Zhang, Binbin^[1];Ni, Shujuan(倪淑娟)^[3]Guo, Weijie^[4];Bian, Zehua^[1];Quan, Chao^[1];Liu, Zhihui^[1];Wang, Yugang^[5];Yu, Jian^[6];Du, Xiang(杜祥)^[3]Hua, Dong^[1];Huang, Zhaohui^[1];
语种：

English
期刊：

ONCOTARGET ISSN：1949-2553 2014 年 5 卷 23 期 (12083 - 12096) ; DEC 15
收录：
关键词：

microRNA-638 TSPAN1 cell proliferation colorectal carcinoma cell cycle
摘要：

The expression of miR-638 was found downregulated in colorectal carcinoma (CRC) in our previous study. However, the role of miR-638 in CRC remains unknown. The aim of this study was to determine the function and mechanism of miR-638 in CRC. Here, we verified that miR-638 was frequently downregulated in CRC tissues compared with corresponding noncancerous tissues (NCTs) in an expanded CRC cohort, and survival analysis showed that the downregulation of miR-638 in CRC was associated with poor prognoses. The ectopic expression of miR-638 inhibited CRC cell proliferation, invasion and arrest the cell cycle in G1 phase, whereas the repression of miR-638 significantly promoted CRC cell growth, invasion and cell cycle G1/S transition. Subsequent mechanism analyses revealed that miR-638 inhibited CRC cell growth, invasion and cell cycle progression by targeting TSPAN1. TSPAN1 protein levels were upregulated in CRC samples and were inversely correlated with miR-638 levels. More importantly, high TSPAN1 expression levels in CRC tissues predicted poor overall survival, and appears to be an independent prognostic factor for CRC survival. Furthermore, CpG island methylation analyses revealed that the miR-638 promoter was hypermethylated in CRC and that attenuating promoter methylation was sufficient to restore miR-638 expression in CRC cells. Taken together, our current data demonstrate that miR-638 functions as a tumor suppressor in human CRC by inhibiting TSPAN1, and that TSPAN1 is a potential prognostic factor for CRC.
推荐引用方式
GB/T 7714：

Zhang Jiwei,Fei Bojian,Wang Qifeng, et al. MicroRNA-638 inhibits cell proliferation, invasion and regulates cell cycle by targeting tetraspanin 1 in human colorectal carcinoma [J].ONCOTARGET,2014,5(23):12083-12096.
APA：

Zhang Jiwei,Fei Bojian,Wang Qifeng,Song Mingxu,&Huang Zhaohui.(2014).MicroRNA-638 inhibits cell proliferation, invasion and regulates cell cycle by targeting tetraspanin 1 in human colorectal carcinoma .ONCOTARGET,5(23):12083-12096.
MLA：

Zhang Jiwei, et al. "MicroRNA-638 inhibits cell proliferation, invasion and regulates cell cycle by targeting tetraspanin 1 in human colorectal carcinoma" .ONCOTARGET 5,23(2014):12083-12096.

浏览次数：18  下载次数：0

分享到：

浏览次数：18

下载次数：0

打印次数：0