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Prospective study of the efficacy of a ketogenic diet in 20 patients with Dravet syndrome 期刊论文

编号：

1fdbf959-a586-423f-a693-49bb18ba75f3
作者：

Ni, Yan^[1];Wang, XinHua^[1];Zhang, LinMei(张林妹)^[1]Chai, YiMing^[1];Li, WenHui(李文辉)^[1]Zhou, YuanFeng(周渊峰)^[1]Zhou, ShuiZhen(周水珍)*^[1]
语种：

英文
期刊：

SEIZURE-EUROPEAN JOURNAL OF EPILEPSY ISSN：1059-1311 2018 年 60 卷 (144 - 148) ; AUG
收录：
关键词：

Dravet syndrome Refractory epilepsy Ketogenic diet SCN1A
摘要：

Purpose: We evaluated the efficacy and tolerability of the ketogenic diet (KD) on generalised convulsions and status epilepticus (SE) in patients with Dravet syndrome (DS).
Methods: Patients with DS having >= 2 generalised convulsions/month despite drug treatment were included in this study and placed on a KD for 6 months. From 3 months before (baseline) to 6 months after KD initiation, caregivers recorded patients' seizure activity, antiepileptic drug use, and adverse events. The KD efficacy was determined by examining the frequency and duration of seizures at 3 and 6 months vs. baseline. Responders were defined as individuals whose generalised convulsions decreased in frequency by >= 50% vs. baseline. Seizures lasting >= 5 min and SE were specifically evaluated. Patients' cognition was also assessed at 3 and 6 months via questionnaire.
Results: Twenty patients continued the KD for at least 3 months. Of the 17 responders identified at month 3, seizures decreased by 50-89% and 90-99% in nine and two patients, respectively; six patients were seizure free. The KD was ineffective in three patients, who discontinued the diet. By month 6, seizures decreased by 50-89% and 90-99% in six and one patient(s), respectively; 10 patients were seizure free. The frequency of other seizure types also improved. During all 6 months, neither generalised convulsions lasting >= 5 min nor SE was detected in the 17 responders. The KD also improved patients' cognition.
Conclusion: The KD is a good treatment option for medically intractable epilepsy.
推荐引用方式
GB/T 7714：

Ni Yan,Wang Xin-Hua,Zhang Lin-Mei, et al. Prospective study of the efficacy of a ketogenic diet in 20 patients with Dravet syndrome [J].SEIZURE-EUROPEAN JOURNAL OF EPILEPSY,2018,60:144-148.
APA：

Ni Yan,Wang Xin-Hua,Zhang Lin-Mei,Chai Yi-Ming,&Zhou Shui-Zhen.(2018).Prospective study of the efficacy of a ketogenic diet in 20 patients with Dravet syndrome .SEIZURE-EUROPEAN JOURNAL OF EPILEPSY,60:144-148.
MLA：

Ni Yan, et al. "Prospective study of the efficacy of a ketogenic diet in 20 patients with Dravet syndrome" .SEIZURE-EUROPEAN JOURNAL OF EPILEPSY 60(2018):144-148.

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