[1]Fudan University, Institute of Biostatistics,Shanghai,China
[2]Zhejiang University, College of Biomedical Engineering and Instrument Science,Hangzhou,China
[3]Fudan University, Department of Biostatistics and Computational Biology,Shanghai,China
[4]s Medical Center,Shanghai,China
[5]Huainan Normal University, Department of Life Science,Huainan,China
[6]Sichuan University, National Engineering Laboratory for Oral Regenerative Medicine,Chengdu,China
The central dogma of gene expression considers RNA as the carrier of genetic information from DNA to protein. However, it has become more and more clear that RNA plays more important roles than simply being the information carrier. Recently, whole genome transcriptomic analyses have identified large numbers of dynamically expressed long noncoding RNAs (lncRNAs), many of which are involved in a variety of biological functions. Even so, the functions and molecular mechanisms of most lncRNAs still remain elusive. Therefore, it is necessary to develop computational methods to predict the function of lncRNAs in order to accelerate the study of lncRNAs. Here, we review the recent progress in the identification of lncRNAs, the molecular functions and mechanisms of lncRNAs, and the computational methods for predicting the function of lncRNAs. © 2012 Handong Ma et al.
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