The nonsynonymous SCN10A single nucleotide polymorphism (SNP) rs6795970 has been reported to associate with PR interval and atrial fibrillation (AF) and in strong linkage disequilibrium (LD) with the AF-associated SNP rs6800541. In this study, we investigated whether rs6795970 polymorphisms are associated with AF recurrence after catheter ablation. A total of 502 consecutive patients with AF who underwent catheter ablation were included. AF recurrence was defined as a documented episode of any atrial arrhythmias lasting >= 30 s after a blanking period of 3 months. AF recurrence was observed between 3 and 12 months after catheter ablation in 24.5% of the patients. There was a significant difference in the allele distribution (p = 7.86 x 10(-5)) and genotype distribution (p = 1.42 x 10(-5)) of rs6795970 between the AF recurrence and no recurrence groups. In a multivariate analysis, we identified the following independent predictors of AF recurrence: the rs6795970 genotypes in an additive model (OR 0.36, 95% CI 0.22 similar to 0.60, p = 7.04 x 10(-5)), a history of AF = 36 months (OR 3.57, 95% CI 2.26 similar to 5.63, p = 4.33 x 10(-8)) and left atrial diameter (LAD) = 40 mm (OR 1.85, 95% CI 1.08 similar to 3.19, p = 0.026). These data suggest that genetic variation in SCN10A may play an important role in predicting AF recurrence after catheter ablation in the Chinese Han population.
[1]Shanghai Jiao Tong Univ, Shanghai First Peoples Hosp, Sch Med, Dept Cardiol, Shanghai 200080, Peoples R China.
[2]Fudan Univ, Zhongshan Hosp, Dept Cardiol, Shanghai 200032, Peoples R China.
[3]Shanghai Songjiang Ctr Hosp, Dept Cardiol, Shanghai 201600, Peoples R China.
[4]Shanghai Jiao Tong Univ, Bio X Inst, Key Lab Genet Dev & Neuropsychiatr Disorders, Minist Educ, Shanghai 200030, Peoples R China.
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