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Correlation between optic disc perfusion and glaucomatous severity in patients with open-angle glaucoma: an optical coherence tomography angiography study 期刊论文 WOS高被引论文

编号：

2128f771-a0da-4860-8a96-1de4ded4dc8b
作者：

Wang, Xiaolei(王晓蕾)#^[1]Jiang, Chunhui(姜春晖)^[1,2]Ko, Tony^[3];Kong, Xiangmei(孔祥梅)^[1,2]Yu, Xiaobo(余晓波)^[1,2]Min, Wang(王敏)^[1,2]Shi, Guohua^[4];Sun, Xinghuai(孙兴怀)*^[1,2,5,6]
语种：

英文
期刊：

GRAEFES ARCHIVE FOR CLINICAL AND EXPERIMENTAL OPHTHALMOLOGY ISSN：0721-832X 2015 年 253 卷 9 期 (1557 - 1564) ; SEP
收录：
关键词：

Open-angle glaucoma Optic disc perfusion Optical coherence tomography angiography
摘要：

To explore how optic disc perfusion varies in patients with open-angle glaucoma (OAG) and how this correlates with glaucoma severity.
We performed a prospective and cross-sectional observational study that included 62 eyes from 62 patients with OAG, divided into three groups according to their visual field (VF) results, and 20 eyes from 20 normal control subjects. Optic disc perfusion was studied using optical coherence tomography angiography (angio-OCT), and flow index and vessel density were determined. The VF, mean deviation (MD), pattern standard deviation (PSD), retinal nerve fiber layer (RNFL) thickness, and ganglion cell complex (GCC) thickness were also recorded. The potential associations between disc perfusion and VF defects or structural loss were analyzed.
In OAG patients, the disc flow index and vessel density were significantly lower than in normal controls (all p < 0.001) and were correlated with the severity of glaucoma. In OAG eyes, the flow index and vessel density were significantly correlated with MD, RNFL, and GCC thickness (all p < 0.01), but were not in the normal controls. The receiver operating characteristic (ROC) curve analysis also revealed that disc flow index and vessel density had the power to differentiate normal eyes from eyes with OAG (under the ROC curves: 0.82 and 0.80, respectively).
Angiograms demonstrated a reduced disc flow index and vessel density in glaucoma, and this reduction was closely related to GCC thickness. This indicated that measurement of disc perfusion by angio-OCT might be important for the monitoring of glaucoma.
推荐引用方式
GB/T 7714：

Wang Xiaolei,Jiang Chunhui,Ko Tony, et al. Correlation between optic disc perfusion and glaucomatous severity in patients with open-angle glaucoma: an optical coherence tomography angiography study [J].GRAEFES ARCHIVE FOR CLINICAL AND EXPERIMENTAL OPHTHALMOLOGY,2015,253(9):1557-1564.
APA：

Wang Xiaolei,Jiang Chunhui,Ko Tony,Kong Xiangmei,&Sun Xinghuai.(2015).Correlation between optic disc perfusion and glaucomatous severity in patients with open-angle glaucoma: an optical coherence tomography angiography study .GRAEFES ARCHIVE FOR CLINICAL AND EXPERIMENTAL OPHTHALMOLOGY,253(9):1557-1564.
MLA：

Wang Xiaolei, et al. "Correlation between optic disc perfusion and glaucomatous severity in patients with open-angle glaucoma: an optical coherence tomography angiography study" .GRAEFES ARCHIVE FOR CLINICAL AND EXPERIMENTAL OPHTHALMOLOGY 253,9(2015):1557-1564.
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