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Fecal bacterial microbiome diversity in chronic HIV-infected patients in China 期刊论文

编号：

21fe679b-aa89-4fbf-814b-a55157430155
作者：

Sun, Yang^[1,2,3];Ma, Yingfei^[4];Lin, Ping^[5];Tang, YiWei^[6];Yang, Liying^[7,8,9];Shen, Yinzhong(沈银忠)^[1]Zhang, Renfan^[1];Liu, Li(刘莉)^[1]Cheng, Jun^[1];Shao, Jiashen^[1];Qi, Tangkai(齐唐凯)^[1]Tang, Yan^[1];Cai, Rentian(蔡仁田)^[1]Guan, Liqian(官丽倩)^[1]Luo, Bin^[1];Sun, Meiyan(孙美艳)^[1]Li, Ben^[3];Pei, Zhiheng^[7,8,9];Lu, Hongzhou(卢洪洲)*^[1]
语种：

English
期刊：

EMERGING MICROBES & INFECTIONS ISSN：2222-1751 2016 年 5 卷 ; APR 6
收录：
关键词：

antiretroviral treatment feces HIV microbiome 16S rRNA
摘要：

The purpose of this study was to identify fecal bacterial microbiome changes in patients with chronic human immunodeficiency virus (HIV) infection in China. Bacterial 16S rRNA genes were amplified, sequenced (454 pyrosequencing), and clustered into operational taxonomic units using the QIIME software. Relative abundance at the phylum and genus levels were calculated. Alpha diversity was determined by Chao 1 and observed-species indices, and beta diversity was determined by double principal component analysis using the estimated phylogeny-based unweighted Unifrac distance matrices. Fecal samples of the patients with chronic HIV-infection tended to be enriched with bacteria of the phyla Firmicutes (47.20%+/- 0.43 relative abundance) and Proteobacteria (37.21%+/- 0.36) compared with those of the non-HIV infected controls (17.95%+/- 0.06 and 3.81%+/- 0.02, respectively). Members of the genus Bilophila were exclusively detected in samples of the non-HIV infected controls. Bacteroides and arabacteroides were more abundant in the chronic HIV-infected patients. Our study indicated that chronic HIV-infected patients in China have a fecal bacterial microbiome composition that is largely different from that found in non-HIV infected controls, and further study is needed to evaluate whether microbiome changes play a role in disease complications in the distal gut, including opportunistic infections.
推荐引用方式
GB/T 7714：

Sun Yang,Ma Yingfei,Lin Ping, et al. Fecal bacterial microbiome diversity in chronic HIV-infected patients in China [J].EMERGING MICROBES & INFECTIONS,2016,5.
APA：

Sun Yang,Ma Yingfei,Lin Ping,Tang Yi-Wei,&Lu Hongzhou.(2016).Fecal bacterial microbiome diversity in chronic HIV-infected patients in China .EMERGING MICROBES & INFECTIONS,5.
MLA：

Sun Yang, et al. "Fecal bacterial microbiome diversity in chronic HIV-infected patients in China" .EMERGING MICROBES & INFECTIONS 5(2016).

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