首页 / 院系成果 / 成果详情页

PROTEIN DEGRADATION BY THE PROTEASOME IS REQUIRED FOR SYNAPTIC TAGGING AND THE HETEROSYNAPTIC STABILIZATION OF HIPPOCAMPAL LATE-PHASE LONG-TERM POTENTIATION 期刊论文

编号：

221cb30e-1b4d-4be7-87b9-b7dccbc4ff33
作者：

Cai, F.^[1,2];Frey, J. U.^[3];Sanna, P. P.^[4];Behnisch, T.*^[1,2]
语种：

English
期刊：

NEUROSCIENCE ISSN：0306-4522 2010 年 169 卷 4 期 (1520 - 1526) ; SEP 15
收录：
关键词：

synaptic plasticity ubiquitin proteasome system hippocampus CA1 heterosynaptic depotentiation
摘要：

Activity-dependent regulation of synaptic efficacy is believed to underlie learning and memory formation. Here we show that protein degradation by the proteasome is required for the induction of the protein synthesis-dependent late-phase of long-term potentiation (late-LTP) but not for its maintenance. Proteasome activity was also key to the polarity of heterosynaptic interactions between synapses expressing synaptic plasticity and newly activated synapses. In fact, proteasome activity was required for the consolidation of an otherwise transient potentiation (early-LTP) into late-LTP by strong tetanization of a separate afferent pathway both in the "weak-before-strong" and in the "strong-before-weak" two-pathway paradigms [Frey and Morris (1997) Nature 385:533 536; Frey and Morris (1998) Neuropharmacology 37:545-552], suggesting that proteasome activity plays a role in the synaptic tagging and capture of plasticity-related proteins at stimulated synapses. Additionally, proteasome inhibition abrogated immunity against heterosynaptic depotentiation of an established late-LTP when applied during weak tetanic stimulation in the "strong-before-weak" two-pathway paradigm. Such a heterosynaptic destabilizing effect of proteasome inhibition was abolished by concomitant inhibition of N-methyl-D-aspartate (NMDA) receptors, suggesting that it is an active process. Together, these results indicate that the proteasome plays important roles in the establishment of late-LTP and in the preservation of potentiated synapses when a subsequent synaptic plasticity is induced within the same neuronal population. (C) 2010 IBRO. Published by Elsevier Ltd. All rights reserved.
推荐引用方式
GB/T 7714：

Cai F.,Frey J. U.,Sanna P. P., et al. PROTEIN DEGRADATION BY THE PROTEASOME IS REQUIRED FOR SYNAPTIC TAGGING AND THE HETEROSYNAPTIC STABILIZATION OF HIPPOCAMPAL LATE-PHASE LONG-TERM POTENTIATION [J].NEUROSCIENCE,2010,169(4):1520-1526.
APA：

Cai F.,Frey J. U.,Sanna P. P.,Behnisch T..(2010).PROTEIN DEGRADATION BY THE PROTEASOME IS REQUIRED FOR SYNAPTIC TAGGING AND THE HETEROSYNAPTIC STABILIZATION OF HIPPOCAMPAL LATE-PHASE LONG-TERM POTENTIATION .NEUROSCIENCE,169(4):1520-1526.
MLA：

Cai F., et al. "PROTEIN DEGRADATION BY THE PROTEASOME IS REQUIRED FOR SYNAPTIC TAGGING AND THE HETEROSYNAPTIC STABILIZATION OF HIPPOCAMPAL LATE-PHASE LONG-TERM POTENTIATION" .NEUROSCIENCE 169,4(2010):1520-1526.

浏览次数：1  下载次数：0

分享到：

浏览次数：1

下载次数：0

打印次数：0