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Fasting activated histaminergic neurons and enhanced arousal effect of caffeine in mice 期刊论文

编号：

221ece43-0e39-4c38-839c-cc3fd245b246
作者：

Wang, YiQun^[1,2];Li, Rui^[1,2,3,4];Wu, Xu(吴旭)^[3,4]Zhu, Fen(朱芬)^[3,4]Takata, Yohko^[5];Zhang, Ze^[6];Zhang, MengQi^[7];Li, ShanQun(李善群)^[3,4]Qu, WeiMin(曲卫敏)^[1,2,6]
语种：

英文
期刊：

PHARMACOLOGY BIOCHEMISTRY AND BEHAVIOR ISSN：0091-3057 2015 年 133 卷 (164 - 173) ; JUN
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关键词：

Caffeine EEG Fasted H1R Wakefulness
摘要：

Caffeine, a popular psychoactive compound, promotes wakefulness via blocking adenosine A(2A) receptors in the shell of the nucleus accumbens, which projects to the arousal histaminergic tuberomammillary nucleus (TMN). The TMN controls several behaviors such as wakefulness and feeding. Fasting has been reported to activate the TMN histaminergic neurons to increase arousal. Therefore, we propose that caffeine may promote greater arousal under fasting rather than normal feeding conditions. In the current study, locomotor activity recording, electroencephalogram (EEG) and electromyogram recording and c-Fos expression were used in wild type (WT) and histamine H-1 receptor (H1R) knockout (KO) mice to investigate the arousal effects of caffeine under fasting conditions. Caffeine (15 mg/kg) enhanced locomotor activity in fasted mice for 5 h, but only did so for 3 h in normally fed animals. Pretreatment with the FliR antagonist pyrilamine abolished caffeine-induced stimulation on locomotor activity in fasted mice. EEG recordings confirmed that caffeine-induced wakefulness for 3 h in fed WT mice, and for 5 h in fasted ones. A stimulatory effect of caffeine was not observed in fasted H1R KO mice. Furthermore, c-Fos expression was increased in the TMN under fasting conditions. These results indicate that caffeine had greater wakefulness-promoting effects in fasted mice through the mediation of H1R. (C) 2015 Elsevier Inc. All rights reserved.
推荐引用方式
GB/T 7714：

Wang Yi-Qun,Li Rui,Wu Xu, et al. Fasting activated histaminergic neurons and enhanced arousal effect of caffeine in mice [J].PHARMACOLOGY BIOCHEMISTRY AND BEHAVIOR,2015,133:164-173.
APA：

Wang Yi-Qun,Li Rui,Wu Xu,Zhu Fen,&Qu Wei-Min.(2015).Fasting activated histaminergic neurons and enhanced arousal effect of caffeine in mice .PHARMACOLOGY BIOCHEMISTRY AND BEHAVIOR,133:164-173.
MLA：

Wang Yi-Qun, et al. "Fasting activated histaminergic neurons and enhanced arousal effect of caffeine in mice" .PHARMACOLOGY BIOCHEMISTRY AND BEHAVIOR 133(2015):164-173.
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