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HDAC3-Selective Inhibition Activates Brown and Beige Fat Through PRDM16 期刊论文

编号：

2335fbff-4593-4ad3-bf59-62c8b43d70be
作者：

Liao, Jiling^[1,2];Jiang, Juan^[1,3];Jun, Heejin^[1];Qiao, Xiaona(乔晓娜)^[1,4]Emont, Margo P.^[1,5];Kim, Dongil^[1];Wu, Jun^[1,5];
语种：

English
期刊：

ENDOCRINOLOGY ISSN：0013-7227 2018 年 159 卷 7 期 (2520 - 2527) ; JUL
收录：
摘要：

It has been reported that class I histone deacetylase (HDAC) inhibition increases thermogenesis in fat, but adipocyte-specific Hdac3 deletions have presented inconsistent results. In this study, we observed that HDAC3 protein levels were lower in brown fat compared with inguinal subcutaneous adipose tissue, and they decreased in both fat depots upon cold exposure. PR domain-containing 16 (PRDM16) physically interacted with HDAC3, and treatment with HDAC3-selective inhibitor RGFP966 induced thermogenic gene expression in murine and human fat cultures. This induction was blunted in the absence of PRDM16. Our results provide evidence that HDAC3 is involved in thermogenesis, suggesting selective inhibition of HDAC3 in brown and beige fat might hold therapeutic potential for counteracting human obesity and metabolic disorders.
推荐引用方式
GB/T 7714：

Liao Jiling,Jiang Juan,Jun Heejin, et al. HDAC3-Selective Inhibition Activates Brown and Beige Fat Through PRDM16 [J].ENDOCRINOLOGY,2018,159(7):2520-2527.
APA：

Liao Jiling,Jiang Juan,Jun Heejin,Qiao Xiaona,&Wu Jun.(2018).HDAC3-Selective Inhibition Activates Brown and Beige Fat Through PRDM16 .ENDOCRINOLOGY,159(7):2520-2527.
MLA：

Liao Jiling, et al. "HDAC3-Selective Inhibition Activates Brown and Beige Fat Through PRDM16" .ENDOCRINOLOGY 159,7(2018):2520-2527.

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