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Assessment of an asymmetrical coating stent with sirolimus released from ablumial matrix in porcine model 期刊论文

编号：

23749a7c-94eb-4db9-a5d4-5f808bac996f
作者：

Shen, Li(沈雳)#^[1]Wu, Yizhe(吴轶喆)^[1]Zhang, Feng(张峰)^[1]Wu, Lingxiang^[2];Dong, Chao^[2];Gao, Yongxing^[1];Sun, Aijun(孙爱军)^[1]Zou, Yunzeng(邹云增)^[1]Qian, Juying(钱菊英)^[1]Sun, Jianguo^[3];Zhong, Wei^[3];Ge, Junbo(葛均波)*^[1]
语种：

英文
期刊：

CLINICAL RESEARCH IN CARDIOLOGY ISSN：1861-0684 2012 年 101 卷 11 期 (917 - 927) ; NOV
收录：
关键词：

Percutaneous coronary intervention Endothelialization In-stent stenosis
摘要：

Delayed endothelialization contributes to stent thrombosis of current drug-eluting stents. The asymmetrical coating technique provides an anti-proliferative effect abluminally without affecting luminal endothelialization. Layer-by-layer self-assembled chitosan/heparin (C/H LBL) has been proved to promote re-endothelialization. A novel stent system, C/H LBL coated luminally and sirolimus released abluminally (C/H LBL-SES), was fabricated.
Bare metal stents (BMS), traditionally circumferential sirolimus-eluting stents (SES), and C/H LBL-SES were implanted into porcine coronary arteries. At the 7, 14 and 28 days follow-up (FU), angiography, intravascular ultrasound (IVUS), vasomotor function induced by acetylcholine (Ach), scanning-electron microscopy and histopathology were performed. Remodeling index (RI) was based on IVUS and defined as cross-sectional area (CSA) of vessel at in-stent segment divided by CSA of reference vessel and expressed as a percentage with a normal range from 0.95 to 1.05.
Thirty-eight mini pigs were enrolled and 74 stents (BMS = 23, C/H LBL = 28, SES = 23) were implanted in this study. At 28 days after implantation, the diameter stenosis of C/H LBL-SES by quantitative coronary angiography was 18.8 +/- A 2.5 %, the area stenosis by histomorphometry was 24.2 +/- A 2.9 %, which were comparable to that of SES and superior to BMS. At 14 days, re-endothelialization of C/H LBL-SES was almost completed, while only about 50 % of surface of SES was covered by endothelium. At 7, 14 and 28 days FU, although C/H LBL-SES suffered a greater vasoconstriction induced by Ach infusion than BMS (P < 0.05), it behaved better than SES (P < 0.01). No sign of stent malapposition was detected, while RI was within the normal range by IVUS. No acute or subacute thrombotic events occurred in all three groups.
The asymmetrically designed C/H LBL-SES successfully inhibited neointima hyperplasia, while diminishing vasoconstriction after Ach-stress. Endothelialization of C/H LBL-SES was less affected compared with traditionally circumferentially coated SES.
推荐引用方式
GB/T 7714：

Shen Li,Wu Yizhe,Zhang Feng, et al. Assessment of an asymmetrical coating stent with sirolimus released from ablumial matrix in porcine model [J].CLINICAL RESEARCH IN CARDIOLOGY,2012,101(11):917-927.
APA：

Shen Li,Wu Yizhe,Zhang Feng,Wu Lingxiang,&Ge Junbo.(2012).Assessment of an asymmetrical coating stent with sirolimus released from ablumial matrix in porcine model .CLINICAL RESEARCH IN CARDIOLOGY,101(11):917-927.
MLA：

Shen Li, et al. "Assessment of an asymmetrical coating stent with sirolimus released from ablumial matrix in porcine model" .CLINICAL RESEARCH IN CARDIOLOGY 101,11(2012):917-927.
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