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Varied association of prothrombin G20210A polymorphism with coronary artery disease susceptibility in different ethnic groups: evidence from 15,041 cases and 21,507 controls 期刊论文

编号：

239d940a-23e4-45bf-b746-74ee69056f54
作者：

Jin, Bo(金波)#^[1]Li, Yong(李勇)^[1]GeShang, QuZhen^[2];Ni, HuanChun(倪唤春)^[1]Shi, HaiMing(施海明)^[1]Shen, Wei(沈伟)*^[1]
语种：

English
期刊：

MOLECULAR BIOLOGY REPORTS ISSN：0301-4851 2011 年 38 卷 4 期 (2371 - 2376) ; APR
收录：
关键词：

Prothrombin G20210A Gene polymorphism Meta-analysis Coronary artery diseases
摘要：

Published data on the association between prothrombin G20210A polymorphism and coronary artery disease (CAD) risk are inconclusive. To derive a more precise estimation of the relationship, a meta-analysis was performed. A total of 42 case-control studies including 15,041 cases and 21,507 controls were included in this meta-analysis. Overall, significantly elevated CAD risk was associated with prothrombin G20210A polymorphism (OR, 1.22; 95% CI 1.07-1.40; P = 0.003) when 39 eligible studies were pooled into the meta-analysis. In the subgroup analysis, borderline statistically increased risk was found for myocardial infarction in 22 case-control studies (OR, 1.27; 95% CI 1.00-1.61; P = 0.05). When stratified by ethnicity, significantly elevated risk was found in Europeans (OR, 1.19; 95% CI, 1.02-1.38; P = 0.02). However, no statistical differences were found among Americans and Asians. In summary, this meta-analysis indicated that prothrombin G20210A allele is a low-penetrant risk factor for developing CAD in Europeans.
推荐引用方式
GB/T 7714：

Jin Bo,Li Yong,Ge-Shang Qu-Zhen, et al. Varied association of prothrombin G20210A polymorphism with coronary artery disease susceptibility in different ethnic groups: evidence from 15,041 cases and 21,507 controls [J].MOLECULAR BIOLOGY REPORTS,2011,38(4):2371-2376.
APA：

Jin Bo,Li Yong,Ge-Shang Qu-Zhen,Ni Huan-Chun,&Shen Wei.(2011).Varied association of prothrombin G20210A polymorphism with coronary artery disease susceptibility in different ethnic groups: evidence from 15,041 cases and 21,507 controls .MOLECULAR BIOLOGY REPORTS,38(4):2371-2376.
MLA：

Jin Bo, et al. "Varied association of prothrombin G20210A polymorphism with coronary artery disease susceptibility in different ethnic groups: evidence from 15,041 cases and 21,507 controls" .MOLECULAR BIOLOGY REPORTS 38,4(2011):2371-2376.

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