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Cell Cycle Inhibition Attenuates Microglial Proliferation and Production of IL-1 beta, MIP-1 alpha, and NO After Focal Cerebral Ischemia in the Rat 期刊论文

编号：

260291e4-71be-46bc-b2c2-7670ffd86376
作者：

Zhang, Qiang^[1];Chen, Chen^[1,2];Lue, Jiagao^[3];Xie, Minjie^[1];Pan, Dengji^[1];Luo, Xiang^[1];Yu, Zhiyuan^[1];Dong, Qiang(董强)^[4]Wang, Wei^[1];
语种：

English
期刊：

GLIA ISSN：0894-1491 2009 年 57 卷 8 期 (908 - 920) ; JUN
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关键词：

microglia cell cycle proliferation apoptosis
摘要：

We recently showed that suppressing cell cycle progression inhibited reactive astrogliosis and promoted neuronal survival in an acute focal cerebral ischemia rat model. However, it remains unclear whether and to what extent the beneficial effects of cell cycle inhibition might also be attributed to the inhibition of microglial proliferation and cytokine/chemokine production. In this study, we showed that application of the cell cycle inhibitor roscovitine before middle carotid artery occlusion (MCAO) in the rat inhibited microglial proliferation and cytokine/chemokine production, and reduced the number of cell-cycle-related proteins including cyclin A, cyclin B, and cyclin E. All of these microglia-related changes may contribute to roscovitine's effect on reducing neuronal apoptosis and infarct volume, thus improving neurological scores. Using the BV-2 microglia cell line, we showed that roscovitine not only inhibited oxygen-glucose deprivation (OGD) induced cell cycle activation by arresting the cells at G1/S and G2/M in a dose-dependent manner, but it also inhibited interleukin-1 beta (IL-1 beta), macrophage inflammatory protein-1 alpha (MIP-1 alpha), and nitric oxide (NO) production. These results suggest that cell cycle modulation results in neuroprotection in ischemia, mediated at least in part through inhibition of microglia proliferation and production of inflammatory cytokines such as IL-1 beta, MIP-1 alpha, and NO. (C) 2008 Wiley-Liss, Inc.
推荐引用方式
GB/T 7714：

Zhang Qiang,Chen Chen,Lue Jiagao, et al. Cell Cycle Inhibition Attenuates Microglial Proliferation and Production of IL-1 beta, MIP-1 alpha, and NO After Focal Cerebral Ischemia in the Rat [J].GLIA,2009,57(8):908-920.
APA：

Zhang Qiang,Chen Chen,Lue Jiagao,Xie Minjie,&Wang Wei.(2009).Cell Cycle Inhibition Attenuates Microglial Proliferation and Production of IL-1 beta, MIP-1 alpha, and NO After Focal Cerebral Ischemia in the Rat .GLIA,57(8):908-920.
MLA：

Zhang Qiang, et al. "Cell Cycle Inhibition Attenuates Microglial Proliferation and Production of IL-1 beta, MIP-1 alpha, and NO After Focal Cerebral Ischemia in the Rat" .GLIA 57,8(2009):908-920.

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