首页 / 院系成果 / 成果详情页

Aurora A Inhibition Eliminates Myeloid Cell-Mediated Immunosuppression and Enhances the Efficacy of Anti-PD-L1 Therapy in Breast Cancer 期刊论文

编号：

27614dae-d324-4a0b-b439-84741a980921
作者：

Yin, Tingting^[1] Zhao, ZhiBin^[2,3] Guo, Jing^[1] Wang, Tianchen^[1] Yang, JingBo^[1] Wang, Chao^[1] Long, Jie^[2,3] Ma, Shisong^[1] Huang, Qiang^[4,5] Zhang, Kaiguang^[4] Ma, Xiaopeng^[4] Liu, Chenhai^[4] Liu, Suing^[6] Lian, ZheXiong^[2,3] Yang, Zhenye^[1]
语种：

英文
期刊：

CANCER RESEARCH ISSN：0008-5472 2019 年 79 卷 13 期 (3431 - 3444) ; JUL 1
收录：
摘要：

The Aurora A inhibitor alisertib shows encouraging activities in clinical trials against advanced breast cancer. However, it remains unclear whether and how the inflammatory microenvironment is involved in its efficacy. Here, we demonstrated that inhibition of Aurora A directly reshaped the immune microenvironment through removal of tumor-promoting myeloid cells and enrichment of anticancer T lymphocytes, which established a tumor-suppressive microenvironment and significantly contributed to the regression of murine mammary tumors. Mechanistically, alisertib treatment triggered apoptosis in myeloid-derived suppressor cells (MDSC) and macrophages, resulting in their elimination from tumors. Furthermore, alisertib treatment disrupted the immunosuppressive functions of MDSC by inhibiting Stat3-mediated ROS production. These alterations led to significant increases of active CD8(+) and CD4(+) T lymphocytes, which efficiently inhibited the proliferation of tumor cells. Intriguingly, alisertib combined with PD-L1 blockade showed synergistic efficacy in the treatment of mammary tumors. These results detail the effects of Aurora A inhibition on the immune microenvironment and provide a novel chemo-immunotherapy strategy for advanced breast cancers.
Significance: These findings show that inhibition of Aurora A facilitates an anticancer immune microenvironment, which can suppress tumor progression and enhance anti-PD-L1 therapy in breast cancer.
推荐引用方式
GB/T 7714：

Yin Tingting,Zhao Zhi-Bin,Guo Jing, et al. Aurora A Inhibition Eliminates Myeloid Cell-Mediated Immunosuppression and Enhances the Efficacy of Anti-PD-L1 Therapy in Breast Cancer [J].CANCER RESEARCH,2019,79(13):3431-3444.
APA：

Yin Tingting,Zhao Zhi-Bin,Guo Jing,Wang Tianchen,&Yang Zhenye.(2019).Aurora A Inhibition Eliminates Myeloid Cell-Mediated Immunosuppression and Enhances the Efficacy of Anti-PD-L1 Therapy in Breast Cancer .CANCER RESEARCH,79(13):3431-3444.
MLA：

Yin Tingting, et al. "Aurora A Inhibition Eliminates Myeloid Cell-Mediated Immunosuppression and Enhances the Efficacy of Anti-PD-L1 Therapy in Breast Cancer" .CANCER RESEARCH 79,13(2019):3431-3444.
条目包含文件：

文件类型：PDF,文件大小：

正在加载全文

未找到全文

浏览次数：35  下载次数：0

分享到：

浏览次数：35

下载次数：0

打印次数：0