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Hypermethylation reduces the expression of PNPLA7 in hepatocellular carcinoma 期刊论文

编号：

27dfdd65-bf16-4989-8031-fffeb6f2e3b3
作者：

Zhang, Xiaojiao^[1,2,3];Zhang, Jun^[1];Wang, Rui(王睿)^[1,2]Guo, Shicheng^[4];Zhang, Huilu^[1];Ma, Yanyun^[4];Liu, Qingmei^[4];Chu, Haiyan^[4];Xu, Xianghong^[4];Zhang, Yitong^[1];Yang, Dongqin^[1];Wang, Jiucun^[4];Liu, Jie(刘杰)^[1,2]
语种：

English
期刊：

ONCOLOGY LETTERS ISSN：1792-1074 2016 年 12 卷 1 期 (670 - 674) ; JUL
收录：
关键词：

hypermethylation demethylation PNPLA7 hepatocellular carcinoma
摘要：

Liver cancer has a high morbidity and mortality rate, and is one of the most common types of cancer in men. PNPLA7 is a member of the patatin-like phospholipase domain-containing protein family which is involved in triglyceride hydrolysis, energy metabolism and lipid droplet metabolism. The liver is the most important energy metabolism organ; whether PNPLA7 is deregulated in liver cancer has not been previously reported. In the present study, reverse transcription-quantitative polymerase chain reaction and subsequent methylation analysis provided evidence that PNPLA7 is down-regulated in hepatocellular carcinoma (HCC) cell lines and tissue samples, via the mechanism of transcriptional silencing by promoter hypermethylation. These results may provide novel insights for HCC diagnosis.
推荐引用方式
GB/T 7714：

Zhang Xiaojiao,Zhang Jun,Wang Rui, et al. Hypermethylation reduces the expression of PNPLA7 in hepatocellular carcinoma [J].ONCOLOGY LETTERS,2016,12(1):670-674.
APA：

Zhang Xiaojiao,Zhang Jun,Wang Rui,Guo Shicheng,&Liu Jie.(2016).Hypermethylation reduces the expression of PNPLA7 in hepatocellular carcinoma .ONCOLOGY LETTERS,12(1):670-674.
MLA：

Zhang Xiaojiao, et al. "Hypermethylation reduces the expression of PNPLA7 in hepatocellular carcinoma" .ONCOLOGY LETTERS 12,1(2016):670-674.

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