首页 / 院系成果 / 成果详情页

Protein Kinase C Lambda Mediates Acid-Sensing Ion Channel 1a-Dependent Cortical Synaptic Plasticity and Pain Hypersensitivity 期刊论文

编号：

29e85b52-1941-41db-b974-a42e3fd37030
作者：

Li, HuSong^[1];Su, XinYu^[1];Song, XingLei^[1];Qi, Xin^[1];Li, Ying^[1];Wang, RuiQi^[1];Maximyuk, Oleksandr^[2];Krishtal, Oleg^[2];Wang, Tingting^[3,4];Fang, Houqin^[3,4];Liao, Lujian^[3,4];Cao, Hong^[5,6];Zhang, YuQiu(张玉秋)^[5,6]Zhu, Michael X.^[7];Liu, MingGang^[1];Xu, TianLe^[1];
语种：

英文
期刊：

JOURNAL OF NEUROSCIENCE ISSN：0270-6474 2019 年 39 卷 29 期 (5773 - 5793) ; JUL 17
收录：
关键词：

acid-sensing ion channel ACC chronic pain long-term potentiation protein kinase C
摘要：

Chronic pain is a serious debilitating disease for which effective treatment is still lacking. Acid-sensing ion channel 1a (ASIC1a) has been implicated in nociceptive processing at both peripheral and spinal neurons. However, whether ASIC1a also contributes to pain perception at the supraspinal level remains elusive. Here, we report that ASIC1a in ACC is required for thermal and mechanical hypersensitivity associated with chronic pain. ACC-specific genetic deletion or pharmacological blockade of ASIC1a reduced the probability of cortical LTP induction and attenuated inflammatory thermal hyperalgesia and mechanical allodynia in male mice. Using cell type-specific manipulations, we demonstrate that ASIC1a in excitatory neurons of ACC is a major player in cortical LTP and pain behavior. Mechanistically, we show that ASIC1a tuned pain-related cortical plasticity through protein kinase C lambda-mediated increase of membrane trafficking of AMPAR subunit GluA1 in ACC. Importantly, postapplication of ASIC1a inhibitors in ACC reversed previously established nociceptive hypersensitivity in both chronic inflammatory pain and neuropathic pain models. These results suggest that ASIC1a critically contributes to a higher level of pain processing through synaptic potentiation in ACC, which may serve as a promising analgesic target for treatment of chronic pain.
推荐引用方式
GB/T 7714：

Li Hu-Song,Su Xin-Yu,Song Xing-Lei, et al. Protein Kinase C Lambda Mediates Acid-Sensing Ion Channel 1a-Dependent Cortical Synaptic Plasticity and Pain Hypersensitivity [J].JOURNAL OF NEUROSCIENCE,2019,39(29):5773-5793.
APA：

Li Hu-Song,Su Xin-Yu,Song Xing-Lei,Qi Xin,&Xu Tian-Le.(2019).Protein Kinase C Lambda Mediates Acid-Sensing Ion Channel 1a-Dependent Cortical Synaptic Plasticity and Pain Hypersensitivity .JOURNAL OF NEUROSCIENCE,39(29):5773-5793.
MLA：

Li Hu-Song, et al. "Protein Kinase C Lambda Mediates Acid-Sensing Ion Channel 1a-Dependent Cortical Synaptic Plasticity and Pain Hypersensitivity" .JOURNAL OF NEUROSCIENCE 39,29(2019):5773-5793.
条目包含文件：

文件类型：PDF,文件大小：

正在加载全文

未找到全文

浏览次数：32  下载次数：0

分享到：

浏览次数：32

下载次数：0

打印次数：0