首页 / 院系成果 / 成果详情页

Amplification of MPZL1/PZR promotes tumor cell migration through Src-mediated phosphorylation of cortactin in hepatocellular carcinoma 期刊论文

编号：

29ea9fd2-811e-4f47-93b1-e0a0ea32ba48
作者：

Jia, Deshui^[1,2];Jing, Ying^[1,2];Zhang, Zhenfeng^[1];Liu, Li^[1];Ding, Jie^[1];Zhao, Fangyu^[1];Ge, Chao^[1];Wang, Qifeng(王奇峰)^[3]Chen, Taoyang^[4];Yao, Ming^[1];Li, Jinjun^[1];Gu, Jianren^[1];He, Xianghuo^[1];
语种：

English
期刊：

CELL RESEARCH ISSN：1001-0602 2014 年 24 卷 2 期 (204 - 217) ; FEB
收录：
关键词：

copy number alterations MPZL1 cortactin migration hepatocellular carcinoma
摘要：

We have previously identified 1 241 regions of somatic copy number alterations (CNAs) in hepatocellular carcinoma (HCC). In the present study, we found that a novel recurrent focal amplicon, 1q24.1-24.2, targets the MPZL1 gene in HCC. Notably, there is a positive correlation between the expression levels of MPZL1 and intrahepatic metastasis of the HCC specimens. MPZL1 can significantly enhance the migratory and metastatic potential of the HCC cells. Moreover, we found that one of the mechanisms by which MPZL1 promotes HCC cell migration is by inducing the phosphorylation and activation of the pro-metastatic protein, cortactin. Additionally, we found that Src kinase mediates the phosphorylation and activation of cortactin induced by MPZL1 overexpression. Taken together, these findings suggest that MPZL1 is a novel pro-metastatic gene targeted by a recurrent region of copy number amplification at 1q24.1-24.2 in HCC.
推荐引用方式
GB/T 7714：

Jia Deshui,Jing Ying,Zhang Zhenfeng, et al. Amplification of MPZL1/PZR promotes tumor cell migration through Src-mediated phosphorylation of cortactin in hepatocellular carcinoma [J].CELL RESEARCH,2014,24(2):204-217.
APA：

Jia Deshui,Jing Ying,Zhang Zhenfeng,Liu Li,&He Xianghuo.(2014).Amplification of MPZL1/PZR promotes tumor cell migration through Src-mediated phosphorylation of cortactin in hepatocellular carcinoma .CELL RESEARCH,24(2):204-217.
MLA：

Jia Deshui, et al. "Amplification of MPZL1/PZR promotes tumor cell migration through Src-mediated phosphorylation of cortactin in hepatocellular carcinoma" .CELL RESEARCH 24,2(2014):204-217.

浏览次数：3  下载次数：0

分享到：

浏览次数：3

下载次数：0

打印次数：0