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Personal exposure to fine particulate matter and blood pressure: A role of angiotensin converting enzyme and its DNA methylation 期刊论文

编号：

2a475e53-24ea-4b4f-b06e-f6bab6760a95
作者：

Wang, Cuicui(汪萃萃)#^[1,2]Chen, Renjie(陈仁杰)^[1,2,3]Cai, Jing(蔡婧)^[1,2]Shi, Jingjin(石晶金)^[1,2]Yang, Changyuan^[1,2];Tse, Lap Ah.^[4];Li, Huichu(李慧楚)^[1,2]Lin, Zhijing^[1,2];Meng, Xia(孟夏)^[1,2]Liu, Cong^[1,2];Niu, Yue^[1,2];Xia, Yongjie^[1,2];Zhao, Zhuohui(赵卓慧)^[1,2]Kan, Haidong(阚海东)*^[1,2,3]
语种：

English
期刊：

ENVIRONMENT INTERNATIONAL ISSN：0160-4120 2016 年 94 卷 (661 - 666) ; SEP
收录：
关键词：

Fine particulate matter Blood pressure Angiotensin-converting enzyme DNA methylation Panel study
摘要：

Background: The underlying intermediate mechanisms about the association between fine particulate matter (PM2.5) air pollution and blood pressure (BP) were unclear. Few epidemiological studies have explored the potential mediation effects of angiotensin-converting enzyme (ACE) and its DNA methylation. Methods: We designed a longitudinal panel study with 4 follow-ups among 36 healthy college students in Shanghai, China from December 17, 2014 to July 11, 2015. We measured personal real-time exposure to PM2.5, serum ACE level, and blood methylation of ACE gene and the repetitive elements. We applied linear mixed-effects models to examine the effects of PM2.5 on ACE protein, DNA methylation and BP markers. Furthermore, we conducted mediation analyses to evaluate the potential pathways. Results: An interquartile range increase (26.78 mu g/m(3)) in 24-h average exposure to PM2.5 was significantly associated with 1.12 decreases in ACE average methylation (%5mC), 13.27% increase in ACE protein, and increments of 1.13 mmHg in systolic BP, 0.66 mmHg in diastolic BP and 0.82 mmHg in mean arterial pressure. ACE hypomethylation mediated 11.78% (P = 0.03) of the elevated ACE protein by PM2.5. Increased ACE protein accounted for 3.90- 13.44% (P = 035 similar to 0.68) of the elevated BP by PM2.5. Repetitive-element methylation was also decreased but did not significantly mediate the association between PM2.5 and BP. Conclusions: This investigation provided strong evidence that short-term exposure to PM2.5 was significantly associated with BP, ACE protein and ACE methylation. Our findings highlighted a possible involvement of ACE and ACE methylation in the effects of PM2.5 on elevating BP. (C) 2016 Elsevier Ltd. All rights reserved.
推荐引用方式
GB/T 7714：

Wang Cuicui,Chen Renjie,Cai Jing, et al. Personal exposure to fine particulate matter and blood pressure: A role of angiotensin converting enzyme and its DNA methylation [J].ENVIRONMENT INTERNATIONAL,2016,94:661-666.
APA：

Wang Cuicui,Chen Renjie,Cai Jing,Shi Jingjin,&Kan Haidong.(2016).Personal exposure to fine particulate matter and blood pressure: A role of angiotensin converting enzyme and its DNA methylation .ENVIRONMENT INTERNATIONAL,94:661-666.
MLA：

Wang Cuicui, et al. "Personal exposure to fine particulate matter and blood pressure: A role of angiotensin converting enzyme and its DNA methylation" .ENVIRONMENT INTERNATIONAL 94(2016):661-666.

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