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Increases in the Risk of Cognitive Impairment and Alterations of Cerebral beta-amyloid Metabolism in Mouse Model of Heart Failure 期刊论文

编号：

2b107f1c-ecbd-4d2d-8352-0271211f38d3
作者：

Hong, Xiaoqi^[1,2];Bu, Liping^[3,4,5];Wang, Yi(王艺)^[1,2]Xu, Jing^[1,2];Wu, Jian(吴剑)^[3,4,5]Huang, Yufang^[1,2];Liu, Jie^[1,2];Suo, Haiyun^[1,2];Yang, Lumeng^[1,2];Shi, Yuncen^[1,2];Lou, Yi^[1,2];Sun, Zhengliang^[1,2];Zhu, Guoqi^[1,2];Behnisch, Thomas^[1,2];Yu, Mei^[1,2];Jia, Jianguo(贾剑国)^[3,4,5]Hai, Wangxi^[8];Meng, Hongping^[9];Liang, Sheng^[9];Huang, Fang(黄芳)^[1,2,6,7]Zou, Yunzeng(邹云增)^[3,4,5]Ge, Junbo(葛均波)^[3,4,5]
语种：

English
期刊：

PLOS ONE ISSN：1932-6203 2013 年 8 卷 5 期 ; MAY 30
收录：
摘要：

Epidemiological and clinico-pathological studies indicate a causal relationship between heart disease and Alzheimer's disease (AD). To learn whether heart disease causes an onset of AD, mice with myocardial infarction (MI) and congestive heart failure (HF) were used to test neuropsychiatric and cognitive behaviors as well as for measurements of AD related protein markers. To this end, adult mice were subjected to ligation of left anterior descending artery (LAD) and about two weeks later high-frequency echocardiography was performed to exam the resulting cardiac structure and function. Three months after successful induction of chronic heart failure (CHF) these mice showed an impairment of learning in the Morris Water Maze task. In addition, the expression of selected molecules, which are involved in beta-amyloid metabolism, apoptosis and inflammation on the level of gene transcription and translation, was altered in CHF mice. Our findings provide a plausible explanation that CHF increases the risk of cognitive impairments and alters cerebral beta-amyloid metabolism. In addition, our data indicate that the cerebral compensatory mechanisms in response to CHF are brain area and gender specific.
推荐引用方式
GB/T 7714：

Hong Xiaoqi,Bu Liping,Wang Yi, et al. Increases in the Risk of Cognitive Impairment and Alterations of Cerebral beta-amyloid Metabolism in Mouse Model of Heart Failure [J].PLOS ONE,2013,8(5).
APA：

Hong Xiaoqi,Bu Liping,Wang Yi,Xu Jing,&Ge Junbo.(2013).Increases in the Risk of Cognitive Impairment and Alterations of Cerebral beta-amyloid Metabolism in Mouse Model of Heart Failure .PLOS ONE,8(5).
MLA：

Hong Xiaoqi, et al. "Increases in the Risk of Cognitive Impairment and Alterations of Cerebral beta-amyloid Metabolism in Mouse Model of Heart Failure" .PLOS ONE 8,5(2013).

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