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Standard diffusion-weighted, diffusion kurtosis and intravoxel incoherent motion MR imaging of sinonasal malignancies: correlations with Ki-67 proliferation status 期刊论文

编号：

2c4e107b-24e8-44b7-82c8-564eaa9cab88
作者：

Xiao, Zebin^[1];Zhong, Yufeng(钟玉凤)^[1,2]Tang, Zuohua(唐作华)*^[1]Qiang, Jinwei^[2];Qian, Wen^[1];Wang, Rong^[1];Wang, Jie^[3];Wu, Lingjie^[4];Tang, Wenlin^[5];Zhang, Zhongshuai^[5];
语种：

English
期刊：

EUROPEAN RADIOLOGY ISSN：0938-7994 2018 年 28 卷 7 期 (2923 - 2933) ; JUL
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关键词：

Neoplasms Magnetic resonance imaging Immunohistochemistry Diffusion magnetic resonance imaging Prognosis
摘要：

To explore the correlations of parameters derived from standard diffusion-weighted imaging (DWI), diffusion kurtosis imaging (DKI) and intravoxel incoherent motion (IVIM) with the Ki-67 proliferation status. Seventy-five patients with histologically proven sinonasal malignancies who underwent standard DWI, DKI and IVIM were retrospectively reviewed. The mean, minimum, maximum and whole standard DWI [apparent diffusion coefficient (ADC)], DKI [diffusion kurtosis (K) and diffusion coefficient (Dk)] and IVIM [pure diffusion coefficient (D), pseudo-diffusion coefficient (D*) and perfusion fraction (f)] parameters were measured and correlated with the Ki-67 labelling index (LI). The Ki-67 LI was categorised as high (> 50%) or low ( 50%). The K and f values were positively correlated with the Ki-67 LI (rho = 0.295 similar to 0.532), whereas the ADC, Dk and D values were negatively correlated with the Ki-67 LI (rho = -0.443 similar to-0.277). The ADC, Dk and D values were lower, whereas the K value was higher in sinonasal malignancies with a high Ki-67 LI than in those in a low Ki-67 LI (all p < 0.05). A higher maximum K value (K-max > 0.977) independently predicted a high Ki-67 status [odds ratio (OR) = 7.614; 95% confidence interval (CI) = 2.197-38.674; p = 0.017]. ADC, Dk, K, D and f are correlated with Ki-67 LI. K-max is the strongest independent factor for predicting Ki-67 status. DWI-derived parameters from different models are capable of providing different pathophysiological information. DWI, DKI and IVIM parameters are associated with Ki-67 proliferation status. K (max) derived from DKI is the strongest independent factor for the prediction of Ki-67 proliferation status.
推荐引用方式
GB/T 7714：

Xiao Zebin,Zhong Yufeng,Tang Zuohua, et al. Standard diffusion-weighted, diffusion kurtosis and intravoxel incoherent motion MR imaging of sinonasal malignancies: correlations with Ki-67 proliferation status [J].EUROPEAN RADIOLOGY,2018,28(7):2923-2933.
APA：

Xiao Zebin,Zhong Yufeng,Tang Zuohua,Qiang Jinwei,&Zhang Zhongshuai.(2018).Standard diffusion-weighted, diffusion kurtosis and intravoxel incoherent motion MR imaging of sinonasal malignancies: correlations with Ki-67 proliferation status .EUROPEAN RADIOLOGY,28(7):2923-2933.
MLA：

Xiao Zebin, et al. "Standard diffusion-weighted, diffusion kurtosis and intravoxel incoherent motion MR imaging of sinonasal malignancies: correlations with Ki-67 proliferation status" .EUROPEAN RADIOLOGY 28,7(2018):2923-2933.

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