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Magnetic mesoporous nanospheres anchored with LyP-1 as an efficient pancreatic cancer probe 期刊论文

编号：

2cad7e9d-87bc-462f-a39a-647918cd749b
作者：

Jiang, Yongjian(蒋永剑)#^[1]Liu, Shaojun^[1];Zhang, Yu^[2];Li, Hengchao^[1];He, Hang(何航)^[1]Dai, Juntao^[1];Jiang, Tao^[3];Ji, Weihang^[4];Geng, Daoying(耿道颖)^[1]Elzatahry, Ahmed A.^[5];Alghamdi, Abdulaziz^[6];Fu, Deliang(傅德良)*^[1]Deng, Yonghui^[2,7];Zhao, Dongyuan^[2];
语种：

English
期刊：

BIOMATERIALS ISSN：0142-9612 2017 年 115 卷 (9 - 18) ; JAN
收录：
关键词：

Pancreatic cancer Molecular imaging Magnetic resonance imaging Superparamagnetic nanospheres LyP-1
摘要：

Immobilization of a ligand that selectively interacts with cancer cells to nanomaterials can enhance their diagnostic and therapeutic efficiency. In this study, we firstly demonstrate the high expression of receptor for cyclic nine-amino acid peptide LyP-1 (Cys-Gly-Asn-Lys-Arg-Thr-Arg-Gly-Cys) in both mouse and human pancreatic cancer. Based on these findings, sub-50 nm multifunctional superparamagnetic mesoporous nanospheres with surface modified with LyP-1 are rationally designed. Theses nanospheres have a core of silica-protected magnetite nanoparticle and a shell of FITC-labeled mesoporous silica, and they are able to specifically recognize and conjugate with the pancreatic cancer cell in vitro, as verified by the combined techniques of fluorescent imaging and T2 weight magnetic resonance imaging. After systematic administration, these LyP-1 immobilized nanospheres are found to actively target to mouse orthotopic xenograft of pancreatic cancer, which opens up the door for applications in early probing and diagnosis of pancreatic cancer by the multimodal imaging. (C) 2016 Elsevier Ltd. All rights reserved.
推荐引用方式
GB/T 7714：

Jiang Yongjian,Liu Shaojun,Zhang Yu, et al. Magnetic mesoporous nanospheres anchored with LyP-1 as an efficient pancreatic cancer probe [J].BIOMATERIALS,2017,115:9-18.
APA：

Jiang Yongjian,Liu Shaojun,Zhang Yu,Li Hengchao,&Zhao Dongyuan.(2017).Magnetic mesoporous nanospheres anchored with LyP-1 as an efficient pancreatic cancer probe .BIOMATERIALS,115:9-18.
MLA：

Jiang Yongjian, et al. "Magnetic mesoporous nanospheres anchored with LyP-1 as an efficient pancreatic cancer probe" .BIOMATERIALS 115(2017):9-18.

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