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TRIM37 promotes epithelial-mesenchymal transition in colorectal cancer 期刊论文

编号：

2d26d4a0-ea5c-4b4d-b755-0bf1a6f6c2c2
作者：

Hu, ChengEn(胡承恩)^[1]Gan, Jun(甘军)^[1]
语种：

English
期刊：

MOLECULAR MEDICINE REPORTS ISSN：1791-2997 2017 年 15 卷 3 期 (1057 - 1062) ; MAR
收录：
关键词：

tripartite motif containing 37 colorectal cancer epithelial-mesenchymal transition
摘要：

There is substantial research on the oncogenic role of tripartite motif containing 37 (TRIM37); however, its importance in colorectal cancer (CRC) remains to be elucidated. The present study used reverse transcription -quantitative polymerase chain reaction, immunohistochemistry and western blotting to detect the expression level of TRIM37 in CRC. The importance of TRIM37 in cell proliferation, invasion and metastasis of CRC were investigated through overexpressing or knocking -down of TRIM37 in CRC cell lines, to observe its function. The present study revealed that TRIM37 was overexpressed in human CRC tissues. High TRIM37 expression resulted in increased CRC proliferation, migration and invasion. Mechanistically, it was confirmed that TRIM37 enhanced invasion and metastasis of CRC via the epithelial-mesenchymal transition pathway. In conclusion, the present study suggested that TRIM3 may contribute to CRC and act as a potential therapeutic target for CRC treatment.
推荐引用方式
GB/T 7714：

Hu Cheng-En,Gan Jun, et al. TRIM37 promotes epithelial-mesenchymal transition in colorectal cancer [J].MOLECULAR MEDICINE REPORTS,2017,15(3):1057-1062.
APA：

Hu Cheng-En,Gan Jun.(2017).TRIM37 promotes epithelial-mesenchymal transition in colorectal cancer .MOLECULAR MEDICINE REPORTS,15(3):1057-1062.
MLA：

Hu Cheng-En, et al. "TRIM37 promotes epithelial-mesenchymal transition in colorectal cancer" .MOLECULAR MEDICINE REPORTS 15,3(2017):1057-1062.

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